msx2 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-852973

Gene Symbol: msx2 Gene Name: msh homeobox 2

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal roof of mouth morphology (2 sources), absent planum trabeculare anticum (2 sources), decreased width of the craniofacial region (2 sources), abnormal Meckel's cartilage morphology (1 source), abnormal basihyal morphology (1 source), abnormal ceratohyal morphology (1 source), abnormal infrarostral morphology (1 source), abnormal mouth morphology (1 source), abnormal palatoquadrati morphology (1 source), abnormal trabecula cranii morphology (1 source), absent suprarostral plate (1 source), decreased size of the craniofacial region (1 source), decreased size of the head mesenchyme (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

abnormal roof of mouth morphology (2 sources), absent planum trabeculare anticum (2 sources), decreased width of the craniofacial region (2 sources), abnormal Meckel's cartilage morphology (1 source), abnormal basihyal morphology (1 source), abnormal ceratohyal morphology (1 source), abnormal infrarostral morphology (1 source), abnormal mouth morphology (1 source), abnormal palatoquadrati morphology (1 source), abnormal trabecula cranii morphology (1 source), absent suprarostral plate (1 source), decreased size of the craniofacial region (1 source), decreased size of the head mesenchyme (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: msx2 assayed (4 sources)
Computed annotations: msx2 assayed (19 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + lhx8 MO + msx2 MO (4 sources), Xla Wt + lhx8 MO + msx2 MO (1 source), Xla Wt + lhx8 MO + msx2 MO + BMS453 (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (29 sources): Aplasia cutis congenita of scalp, Bicoronal synostosis, Brachycephaly, Brachydactyly, Brachyturricephaly, Cleft palate, Cleft soft palate, Cleft upper lip, Craniosynostosis, Dermoid cyst, Encephalocele, Frontal bossing, Headache, Hypermetropia, Hypotelorism, Macrocephaly, Microtia, Myopia, Parietal foramina, Seizure, Short clavicles, Supernumerary tooth, Symmetrical, oval parietal bone defects, Trigonocephaly, Triphalangeal thumb, Turricephaly, Unicoronal synostosis, Visual field defect, Widely patent fontanelles and sutures [+]
Mouse (70 sources): abnormal cerebellum anterior vermis morphology, abnormal cerebellum development, abnormal dermal layer morphology, abnormal ear morphology, abnormal enamel organ morphology, abnormal epidermis stratum basale morphology, abnormal eye development, abnormal frontal bone morphology, abnormal hair follicle bulb morphology, abnormal hair follicle inner root sheath morphology, abnormal hair follicle matrix region morphology, abnormal hair follicle morphology, abnormal hair follicle orientation, abnormal hair shedding, abnormal lens vesicle development, abnormal long bone hypertrophic chondrocyte zone, abnormal mammary gland embryonic development, abnormal nail matrix morphology, abnormal nail morphology, abnormal neurocranium morphology, abnormal optic vesicle formation, abnormal retina pigment epithelium morphology, abnormal skeleton development, abnormal stellate reticulum morphology, abnormal stratum intermedium morphology, absent cerebellum vermis lobule IX, absent cerebellum vermis lobule VIII, ameloblast degeneration, behavior/neurological phenotype, brittle teeth, cardiovascular system phenotype, chondrodystrophy, curly vibrissae, decreased chondrocyte number, decreased corneal epithelium thickness, decreased osteoclast cell number, deformed nails, degenerate molars, delaminated Purkinje cell layer, delaminated cerebellar granule layer, delayed hair regrowth, dermis papillary layer hypercellularity, disorganized inner root sheath cells, disorganized matrix sheath cells, disorganized outer root sheath cells, disorganized suprabasal layer, distorted hair follicle pattern, ectopic cranial bone, embryonic growth retardation, epidermal desquamation, flaky skin, focal hair loss, frontal bone foramen, increased corneal stroma thickness, integument phenotype, iris hyperplasia, long nails, long toenails, nervous system phenotype, no abnormal phenotype detected, premature hair loss, short hair, short vibrissae, small interparietal bone, small supraoccipital bone, thick epidermis suprabasal layer, thick skin, thin hair follicle outer root sheath, tonic seizures, vitreous body deposition [+]
View all ortholog results at Monarch