| Monarch Ortholog Phenotypes
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Human (7 sources):
Acute myeloid leukemia,
Anemia,
Bruising susceptibility,
Epistaxis,
Neutropenia,
Petechiae,
Thrombocytopenia
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Mouse (36 sources):
abnormal blood uric acid level,
abnormal bone marrow cell physiology,
abnormal circulating calcium level,
abnormal circulating cholesterol level,
abnormal circulating total protein level,
abnormal common lymphocyte progenitor cell morphology,
abnormal common myeloid progenitor cell morphology,
abnormal definitive hematopoiesis,
abnormal erythropoiesis,
abnormal lymphopoiesis,
abnormal megakaryocyte differentiation,
abnormal myeloblast morphology/development,
abnormal visceral yolk sac morphology,
absent vitelline blood vessels,
arrested B cell differentiation,
cardiovascular system phenotype,
decreased pre-B cell number,
decreased pro-B cell number,
embryo phenotype,
embryonic growth retardation,
embryonic lethality during organogenesis, complete penetrance,
embryonic lethality during organogenesis, incomplete penetrance,
enlarged pericardium,
immune system phenotype,
increased hematopoietic stem cell number,
increased incidence of tumors by chemical induction,
increased mammary gland tumor incidence,
mammary gland alveolar hyperplasia,
myeloid hyperplasia,
no abnormal phenotype detected,
postnatal lethality,
premature death,
prenatal lethality, complete penetrance,
preweaning lethality, complete penetrance,
preweaning lethality, incomplete penetrance,
small liver
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.