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Summary Expression Phenotypes Gene Literature (145) GO Terms (8) Nucleotides (324) Proteins (53) Interactants (1034) Wiki
XB-GENEPAGE-855582

cyp26a1     cytochrome P450 family 26 subfamily A member 1

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
decreased size of the head (6 sources), decreased size of the cement gland (5 sources), absent eye (4 sources), abnormal development of eye (2 sources)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: cyp26a1 manipulated (3 sources), cyp26a1 assayed (4 sources)
Computed annotations: cyp26a1 manipulated (3 sources), cyp26a1 assayed (22 sources)
Diseases
Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
microcephaly (4AP sources, 2 EP sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + cyp26a1 (1 source), Xla Wt + cyp26a1 (1 source), Xla Wt + cyp26a1 (1 source), Xla Wt + cyp26a1 + aldh1a2 MO (1 source), Xla Wt + cyp26a1 + aldh1a3 MO (1 source), Xla Wt + cyp26a1 + DEAB (1 source), Xla Wt + cyp26a1 + DEAB (1 source), Xla Wt + nog + vegt + cyp26a1 + Retinoic acid + animal cap explant (1 source), Xla Wt + nog + vegt + cyp26a1 + Retinoic acid + CHX + animal cap explant (1 source), Xla Wt + vegt + nog + cyp26a1 + CHX + animal cap explant (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (33 sources): abnormal digestive system development, abnormal heart development, abnormal heart looping, abnormal hindbrain development, abnormal hindgut morphology, abnormal hindlimb morphology, abnormal kidney morphology, abnormal maxillary nerve morphology, abnormal mesonephros morphology, abnormal ophthalmic nerve morphology, [+]