ext1 Phenotypes

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Phenotypes

Gene Literature (7)

Nucleotides (211)

Interactants (276)

XB-GENEPAGE-867524

Gene Symbol: ext1 Gene Name: exostosin glycosyltransferase 1

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal axis elongation (2 sources), abnormal head morphology (2 sources), abnormal tail morphology (2 sources), decreased length of anterior-posterior axis (2 sources), abnormal bending of anterior-posterior axis (1 source), abnormal development of embryo (1 source), abnormal gastrulation (1 source), abnormally delayed closure of blastopore (1 source), wholly ventralized embryo (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: ext1 assayed (3 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + ext1 MO (4 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (44 sources): Abnormal foot morphology, Abnormal pericardium morphology, Abnormal pyramidal sign, Abnormality of femur morphology, Abnormality of pelvic girdle bone morphology, Abnormality of the dentition, Abnormality of the humerus, Abnormality of the metaphysis, Abnormality of the skeletal system, Abnormality of the upper limb, Abnormality of tibia morphology, Anteverted nares, Avascular necrosis, Bone pain, Cervical myelopathy, Chondrosarcoma, Coxa vara, Cranial nerve paralysis, Elbow dislocation, Exostoses, Failure to thrive, Genu valgum, Hemiplegia/hemiparesis, Hypoplasia of the ulna, Madelung deformity, Madelung-like forearm deformities, Micromelia, Multiple exostoses, Muscle weakness, Neoplasm, Osteoarthritis, Osteolysis, Pelvic bone exostoses, Peripheral nerve compression, Protuberances at ends of long bones, Radial bowing, Recurrent fractures, Rib exostoses, Scapular exostoses, Scoliosis, Short metacarpal, Short stature, Synostosis of joints, Vascular dilatation [+]
Mouse (52 sources): abnormal axon guidance, abnormal basicranium morphology, abnormal brain commissure morphology, abnormal brain development, abnormal cartilage development, abnormal cerebral cortex morphology, abnormal corneal stroma morphology, abnormal cranial synchondrosis, abnormal craniofacial morphology, abnormal developmental patterning, abnormal ear morphology, abnormal embryonic tissue morphology, abnormal epiphyseal plate morphology, abnormal excitatory postsynaptic currents, abnormal extraembryonic tissue morphology, abnormal forelimb morphology, abnormal iridocorneal angle, abnormal limb morphology, abnormal long bone epiphyseal plate proliferative zone, abnormal miniature excitatory postsynaptic currents, abnormal nest building behavior, abnormal social investigation, absent anterior commissure, absent cerebellum, absent hard palate, absent hippocampal commissure, absent inferior colliculus, absent mesoderm, absent olfactory bulb, decreased anxiety-related response, decreased cranial neural crest cell proliferation, decreased embryo size, decreased eye anterior chamber depth, decreased fear-related response, decreased thermal nociceptive threshold, decreased vocalization, disorganized embryonic tissue, embryonic lethality, embryonic lethality between implantation and somite formation, complete penetrance, embryonic lethality during organogenesis, complete penetrance, failure of primitive streak formation, failure to gastrulate, increased diameter of radius, increased diameter of ulna, neonatal lethality, complete penetrance, no abnormal phenotype detected, premature death, prenatal lethality, complete penetrance, prenatal lethality, incomplete penetrance, preweaning lethality, complete penetrance, reduced AMPA-mediated synaptic currents, thin cerebral cortex [+]
View all ortholog results at Monarch