neurog3 Phenotypes

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Phenotypes

Gene Literature (27)

Nucleotides (85)

Interactants (320)

XB-GENEPAGE-876278

Gene Symbol: neurog3 Gene Name: neurogenin 3

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal type B pancreatic cell differentiation (3 sources)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: neurog3 manipulated (19 sources), neurog3 assayed (3 sources)
Computed annotations: neurog3 assayed (15 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + neurog3-GR + DEX (7 sources), Xla Wt + neurog3-GR + DEX (7 sources), Xla Wt + Mmu.neurog3-GR + DEX (2 sources), Xla Wt + Hsa.neurog3-GR + DEX (1 source), Xla Wt + neurog3-GR + insm1 MO + DEX (1 source), Xla Wt + neurog3-GR + rfx6 MO + DEX (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (10 sources): Abnormal cellular phenotype, Cholestatic liver disease, Dehydration, Diarrhea, Failure to thrive, Hyperchloremic metabolic acidosis, Malabsorption, Portal hypertension, Type I diabetes mellitus, Vomiting
Mouse (39 sources): abnormal abdominal fat pad morphology, abnormal endocrine pancreas morphology, abnormal intestinal enteroendocrine cell morphology, abnormal intestinal goblet cell morphology, abnormal intestinal lipid absorption, abnormal intestinal transit time, abnormal intestine development, abnormal pancreas development, abnormal pancreatic acinar cell morphology, abnormal pancreatic alpha cell morphology, abnormal pancreatic beta cell morphology, abnormal pancreatic delta cell morphology, abnormal pancreatic islet morphology, abnormal small intestinal crypt cell proliferation, abnormal small intestinal microvillus morphology, abnormal small intestine crypts of Lieberkuhn morphology, absent pancreatic alpha cells, absent pancreatic beta cells, absent pancreatic islets, decreased birth weight, decreased body mass index, decreased body size, decreased circulating glucose level, decreased small intestinal microvillus size, disorganized stomach mucosa, improved glucose tolerance, increased circulating bicarbonate level, increased circulating glucose level, increased defecation amount, increased insulin sensitivity, increased lean body mass, increased stomach mucosa thickness, no abnormal phenotype detected, pancreatic acinar cell zymogen granule accumulation, postnatal lethality, complete penetrance, postnatal lethality, incomplete penetrance, regional gastric metaplasia, small pancreatic islets, small stomach [+]
View all ortholog results at Monarch