mark2 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-876450

Gene Symbol: mark2 Gene Name: microtubule affinity regulating kinase 2

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
decreased length of anterior-posterior axis (2 sources), abnormal bending of tail (1 source), abnormal development of embryo (1 source), decreased size of the eye (1 source), wholly ventralized embryo (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: mark2 manipulated (4 sources)
Computed annotations: mark2 assayed (13 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + mark2 MO (4 sources), Xtr Wt + mark2 MO (2 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (43 sources): abnormal CD4-positive, alpha beta T cell morphology, abnormal glomerular capillary morphology, abnormal humoral immune response, abnormal spleen B cell follicle morphology, decreased B cell proliferation, decreased IgG3 level, decreased body length, decreased brown adipose tissue amount, decreased circulating adiponectin level, decreased circulating insulin-like growth factor I level, decreased circulating progesterone level, decreased circulating prolactin level, decreased corpora lutea number, decreased embryo weight, decreased epididymis weight, decreased litter size, decreased ovary weight, decreased percent body fat/body weight, decreased seminal vesicle weight, decreased susceptibility to diet-induced obesity, decreased susceptibility to hepatic steatosis, decreased susceptibility to weight gain, decreased testis weight, decreased uterus weight, decreased white adipose tissue amount, enlarged lung, enlarged lymph nodes, improved glucose tolerance, increased B cell proliferation, increased adipocyte glucose uptake, increased basal metabolism, increased brain size, increased energy expenditure, increased insulin sensitivity, increased interferon-gamma secretion, increased interleukin-4 secretion, increased mesangial cell number, increased renal glomerulus lobularity, increased spleen weight, postnatal lethality, incomplete penetrance, reduced female fertility, salivary gland inflammation, spleen hyperplasia [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (43 sources): abnormal CD4-positive, alpha beta T cell morphology, abnormal glomerular capillary morphology, abnormal humoral immune response, abnormal spleen B cell follicle morphology, decreased B cell proliferation, decreased IgG3 level, decreased body length, decreased brown adipose tissue amount, decreased circulating adiponectin level, decreased circulating insulin-like growth factor I level, [+]