| Monarch Ortholog Phenotypes
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Human (26 sources):
Abnormal respiratory system physiology,
Agitation,
Amyotrophic lateral sclerosis,
Anxiety,
Degeneration of anterior horn cells,
Depression,
Dyspnea,
Emotional lability,
Fatigable weakness of bulbar muscles,
Fatigable weakness of respiratory muscles,
Fatigable weakness of swallowing muscles,
Fatigue,
Generalized muscle weakness,
Hepatic fibrosis,
Laryngospasm,
Loss of ability to walk,
Muscle spasm,
Nausea and vomiting,
Neurodegeneration,
Pain,
Paralysis,
Respiratory insufficiency,
Respiratory insufficiency due to muscle weakness,
Skeletal muscle atrophy,
Spasticity,
Xerostomia
[+]
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Mouse (28 sources):
abnormal blood flow velocity,
abnormal cranial ganglia morphology,
abnormal geniculate ganglion morphology,
abnormal impulse conducting system conduction,
abnormal intercalated disk morphology,
abnormal lactation,
abnormal mammary gland development,
abnormal mammary gland growth during lactation,
abnormal motor neuron innervation pattern,
abnormal myocardial fiber morphology,
abnormal prepulse inhibition,
abnormal sensory neuron innervation pattern,
abnormal trigeminal ganglion morphology,
abnormal vestibulocochlear ganglion morphology,
absent trabeculae carneae,
behavior/neurological phenotype,
cardiac hypertrophy,
decreased atrioventricular cushion size,
decreased cardiac muscle contractility,
decreased myocardial fiber number,
decreased prepulse inhibition,
dilated heart left ventricle,
embryonic lethality during organogenesis, complete penetrance,
enhanced long term potentiation,
no abnormal phenotype detected,
premature death,
prolonged QRS complex duration,
thin ventricular wall
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.