| Monarch Ortholog Phenotypes
|
|
Human (7 sources):
Abnormal salivary gland morphology,
Anodontia,
Cleft palate,
Cleft upper lip,
Hypodontia,
Lip pit,
Lower lip pit
|
Mouse (43 sources):
abnormal brain development,
abnormal corneocyte envelope morphology,
abnormal corneocyte morphology,
abnormal craniofacial development,
abnormal dorsal-ventral axis patterning,
abnormal epidermis stratum basale morphology,
abnormal epidermis stratum corneum morphology,
abnormal epidermis stratum granulosum morphology,
abnormal keratinocyte differentiation,
abnormal lipid level,
abnormal locomotor activation,
abnormal palate development,
abnormal periderm development,
abnormal stomach epithelium morphology,
abnormal vertebral spinous process morphology,
absent vertebral arch,
curly tail,
decreased blood urea nitrogen level,
decreased circulating alkaline phosphatase level,
decreased embryo size,
delayed neural tube closure,
epidermal hyperplasia,
excessive scratching,
eyelids open at birth,
fetal growth retardation,
impaired skin barrier function,
increased circulating glucose level,
increased incidence of tumors by chemical induction,
increased keratinocyte proliferation,
increased skin papilloma incidence,
increased tumor incidence,
integument phenotype,
intestinal hemorrhage,
kinked tail,
lethality during fetal growth through weaning, complete penetrance,
nervous system phenotype,
no abnormal phenotype detected,
open neural tube,
perinatal lethality, complete penetrance,
preweaning lethality, complete penetrance,
skin lesions,
spina bifida cystica,
thick epidermis stratum spinosum
[+]
|
View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.