Advanced eruption of teeth, Asymmetry of the breasts, Brachydactyly, Cachexia, Cholestasis, Clitoral hypertrophy, Coarse facial features, Coarse hair, Cognitive impairment, Coma, Cryptorchidism, Delayed puberty, Delayed skeletal maturation, Depressed nasal bridge, Diabetes mellitus, Diabetic ketoacidosis, Dry skin, Elevated circulating growth hormone concentration, Elfin facies, Failure to thrive, Fasting hyperinsulinemia, Fasting hypoglycemia, Fatigue, Feeding difficulties in infancy, Female pseudohermaphroditism, Generalized hirsutism, Generalized hyperpigmentation, Gingival overgrowth, Global developmental delay, Gynecomastia, Hearing abnormality, Hepatic fibrosis, High palate, High, narrow palate, Hyperglycemia, Hyperinsulinemia, Hyperinsulinemic hypoglycemia, Hyperkeratosis, Hypermelanotic macule, Hypertelorism, Hypertrichosis, Hypoglycemia, Hypoglycemic coma, Hypoglycemic seizures, Insulin resistance, Insulin-resistant diabetes mellitus, Intrauterine growth retardation, Large hands, Lipoatrophy, Long foot, Long penis, Low-set ears, Low-set, posteriorly rotated ears, Macrotia, Mandibular prognathia, Microcephaly, Myopia, Nail dysplasia, Onychauxis, Onychogryposis, Ovarian cyst, Pancreatic islet-cell hyperplasia, Peripheral neuropathy, Polycystic ovaries, Postprandial hyperglycemia, Precocious puberty, Prematurely aged appearance, Prominent nipples, Proptosis, Proteinuria, Recurrent hypoglycemia, Recurrent infections, Recurrent respiratory infections, Seizure, Severe failure to thrive, Short stature, Skeletal muscle atrophy, Small face, Small for gestational age, Subcutaneous nodule, Thick lower lip vermilion, Thick nasal alae, Thickened nuchal skin fold, Thickened skin, Type II diabetes mellitus, Umbilical hernia, Wide mouth

abnormal pancreatic beta cell morphology, abnormal pancreatic islet morphology, abnormal seminiferous tubule morphology, cardiovascular system phenotype, decreased Leydig cell number, decreased cardiac cell glucose uptake, decreased cardiac muscle contractility, decreased cardiac output, decreased circulating free fatty acids level, decreased circulating glucose level, decreased coronary flow rate, decreased corpora lutea number, decreased insulin secretion, decreased liver glycogen level, decreased pancreatic beta cell mass, decreased sensitivity to induced morbidity/mortality, decreased sensitivity to xenobiotic induced morbidity/mortality, digestive/alimentary phenotype, enlarged gallbladder, growth/size/body region phenotype, homeostasis/metabolism phenotype, impaired ovarian folliculogenesis, increased bile salt level, increased brown fat cell lipid droplet size, increased cardiac cell glucose uptake, increased cardiac muscle glycogen level, increased circulating alkaline phosphatase level, increased circulating aspartate transaminase level, increased circulating glucose level, increased fatty acids level, increased insulin secretion, increased insulin sensitivity, increased mitochondrial size, increased oxygen consumption, increased pancreatic beta cell mass, increased sensitivity to induced morbidity/mortality, increased susceptibility to induced colitis, increased triglyceride level, increased white adipose tissue amount, ketoacidosis, nervous system phenotype, pancreatic islet hyperplasia, postnatal lethality, postnatal lethality, complete penetrance, premature death, reduced male fertility, skeletal muscle hypotrophy, small heart, small liver, small myocardial fiber, thin ventricular wall