Monarch Ortholog Phenotypes
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Human (75 sources):
Abnormal bleeding,
Abnormal circulating interleukin concentration,
Abnormal circulating vitamin B12 concentration,
Abnormal proportion of CD4-positive T cells,
Abnormal proportion of CD8-positive T cells,
Anti-smooth muscle antibody positivity,
Antineutrophil antibody positivity,
Antinuclear antibody positivity,
Antiphospholipid antibody positivity,
Arthritis,
Autoimmune hemolytic anemia,
Autoimmune thrombocytopenia,
Autoimmunity,
B-cell lymphoma,
Basal cell carcinoma,
Bone marrow hypercellularity,
Bone marrow hypocellularity,
Bruising susceptibility,
Burkitt lymphoma,
Chronic noninfectious lymphadenopathy,
Colitis,
Coombs-positive hemolytic anemia,
Decreased circulating IgG level,
Decreased circulating total IgM,
Decreased lymphocyte apoptosis,
Decreased proportion of CD4-positive helper T cells,
Decreased specific anti-polysaccharide antibody level,
Elevated proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells,
Eosinophilia,
Fibroadenoma of the breast,
Follicular hyperplasia,
Gastritis,
Glomerulonephritis,
Headache,
Hepatitis,
Hepatocellular carcinoma,
Hepatomegaly,
Hodgkin lymphoma,
Hydrops fetalis,
Hypersplenism,
Increased B cell count,
Increased circulating IgA level,
Increased circulating IgE level,
Increased circulating IgG level,
Increased circulating IgM level,
Increased circulating antibody level,
Increased proportion of HLA DR+ T cells,
Iron deficiency anemia,
Lymphadenopathy,
Lymphocytosis,
Lymphopenia,
Neoplasm of the skin,
Neoplasm of the tongue,
Neutropenia in presence of anti-neutropil antibodies,
Non-Hodgkin lymphoma,
Panniculitis,
Platelet antibody positive,
Premature ovarian insufficiency,
Pulmonary fibrosis,
Pulmonary infiltrates,
Recurrent aphthous stomatitis,
Reduced delayed hypersensitivity,
Renal insufficiency,
Reticulocytosis,
Rheumatoid factor positive,
Seizure,
Splenomegaly,
Systemic lupus erythematosus,
T-cell lymphoma,
Thyroid adenoma,
Thyroid carcinoma,
Thyroiditis,
Urticaria,
Uveitis,
Vasculitis
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Mouse (133 sources):
CNS inflammation,
abnormal B cell activation,
abnormal B cell receptor editing,
abnormal T cell clonal deletion,
abnormal T cell differentiation,
abnormal T cell proliferation,
abnormal T-helper 2 physiology,
abnormal airway responsiveness,
abnormal apoptosis,
abnormal conjunctival epithelium morphology,
abnormal coronary artery morphology,
abnormal cytotoxic T cell physiology,
abnormal gland morphology,
abnormal glomerular capillary endothelium morphology,
abnormal glomerular capillary morphology,
abnormal hepatocyte morphology,
abnormal hypersensitivity reaction,
abnormal immune system organ morphology,
abnormal interleukin level,
abnormal kidney morphology,
abnormal leukocyte adhesion,
abnormal lymph node cell ratio,
abnormal lymph organ size,
abnormal marginal zone B cell morphology,
abnormal myocardium layer morphology,
abnormal renal glomerulus basement membrane morphology,
abnormal renal glomerulus morphology,
abnormal skin condition,
abnormal spatial learning,
abnormal spleen periarteriolar lymphoid sheath morphology,
abnormal splenic cell ratio,
abnormal stria vascularis morphology,
abnormal stria vascularis vasculature morphology,
abnormal strial intermediate cell morphology,
abnormal submandibular gland morphology,
abnormal thymus involution,
abnormal thymus medulla morphology,
abnormal thyroid follicle morphology,
abnormal type III hypersensitivity reaction,
abnormal vagina weight,
alveolitis,
autoimmune response,
blood vessel inflammation,
cardiovascular system phenotype,
cortical renal glomerulopathies,
decreased B cell apoptosis,
decreased CD4-positive, alpha beta T cell number,
decreased activated T cell number,
decreased apoptosis,
decreased eosinophil cell number,
decreased hepatocyte apoptosis,
decreased immature B cell number,
decreased interleukin-2 secretion,
decreased macrophage apoptosis,
decreased marginal zone B cell number,
decreased mature B cell number,
decreased neuron apoptosis,
decreased spleen germinal center number,
decreased susceptibility to autoimmune diabetes,
decreased susceptibility to experimental autoimmune encephalomyelitis,
decreased transitional stage B cell number,
dilated renal glomerular capsule,
endocrine/exocrine gland phenotype,
enlarged Peyer's patches,
enlarged lymph nodes,
enlarged thymus,
epidermal necrosis,
focal hepatic necrosis,
glomerular crescent,
immune system phenotype,
impaired leukocyte tethering or rolling,
increased IgG1 level,
increased IgG2a level,
increased IgG2b level,
increased IgG3 level,
increased NK cell number,
increased T cell apoptosis,
increased activated T cell number,
increased anti-double stranded DNA antibody level,
increased anti-erythrocyte antigen antibody level,
increased anti-histone antibody level,
increased anti-nuclear antigen antibody level,
increased anti-single stranded DNA antibody level,
increased apoptosis,
increased autoantibody level,
increased central memory CD4-positive, alpha-beta T cell number,
increased dendritic cell number,
increased double-negative T cell number,
increased double-positive T cell number,
increased effector memory CD4-positive, alpha-beta T cell number,
increased follicular B cell number,
increased gamma-delta T cell number,
increased immature B cell number,
increased kidney cell proliferation,
increased marginal zone B cell number,
increased memory T cell number,
increased mesangial cell number,
increased neutrophil cell number,
increased or absent threshold for auditory brainstem response,
increased plasma cell number,
increased renal glomerulus apoptosis,
increased renal glomerulus basement membrane thickness,
increased sensitivity to induced morbidity/mortality,
increased spleen weight,
increased splenocyte number,
increased susceptibility to Picornaviridae infection,
increased susceptibility to autoimmune disorder,
increased susceptibility to parasitic infection,
increased susceptibility to systemic lupus erythematosus,
increased susceptibility to type III hypersensitivity reaction,
increased thymus weight,
increased transitional stage B cell number,
increased tumor incidence,
lacrimal gland atrophy,
lacrimal gland inflammation,
liver hyperplasia,
lymph node hemorrhage,
lymph node necrosis,
lymphoid hyperplasia,
no abnormal phenotype detected,
podocyte foot process effacement,
premature death,
renal cast,
renal glomerular immunoglobulin deposits,
renal glomerular protein deposits,
renal glomerulus hypertrophy,
ruffled hair,
salivary gland inflammation,
skin lesions,
submandibular gland inflammation,
thymus atrophy,
thymus cortex atrophy,
vision/eye phenotype
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View all ortholog results at Monarch
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