| Monarch Ortholog Phenotypes
|
Human (40 sources):
Abnormal motor nerve conduction velocity,
Ankle clonus,
Babinski sign,
Brisk reflexes,
Bulbar signs,
Cold-induced hand cramps,
Difficulty running,
Difficulty walking,
Distal amyotrophy,
Distal lower limb muscle weakness,
Distal sensory impairment,
Dysarthria,
Dysphagia,
First dorsal interossei muscle atrophy,
First dorsal interossei muscle weakness,
Gait disturbance,
Hammertoe,
Hand muscle weakness,
Hyperreflexia,
Hyperreflexia in upper limbs,
Impaired proprioception,
Impaired vibratory sensation,
Lower limb hyperreflexia,
Lower limb muscle weakness,
Lower limb spasticity,
Motor polyneuropathy,
Pes cavus,
Pes valgus,
Proximal lower limb amyotrophy,
Proximal muscle weakness in lower limbs,
Skeletal muscle atrophy,
Spastic gait,
Spastic paraplegia,
Spastic tetraparesis,
Spasticity,
Thenar muscle atrophy,
Thenar muscle weakness,
Unsteady gait,
Upper limb muscle weakness,
Urinary urgency
[+]
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Mouse (10 sources):
abnormal axon morphology,
abnormal cerebral cortex morphology,
abnormal endoplasmic reticulum morphology,
abnormal fat cell differentiation,
abnormal fat cell morphology,
abnormal locomotor behavior,
decreased abdominal adipose tissue amount,
decreased white fat cell lipid droplet size,
increased glutamic acid level,
slow movement
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.