irf1 Phenotypes

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Phenotypes

Gene Literature (7)

Nucleotides (146)

Interactants (301)

XB-GENEPAGE-942993

Gene Symbol: irf1 Gene Name: interferon regulatory factor 1

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: irf1 assayed (10 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (4 sources): Abnormality of the respiratory system, Alveolar cell carcinoma, Increased level of L-fucose in urine, Stomach cancer
Mouse (39 sources): abnormal T cell proliferation, abnormal circulating alanine transaminase level, abnormal circulating interleukin-10 level, abnormal circulating interleukin-4 level, abnormal cytokine level, abnormal lymphocyte physiology, abnormal macrophage physiology, abnormal response to infection, abnormal splenocyte morphology, abnormal thymus cell ratio, abnormal vascular wound healing, cellular phenotype, decreased circulating interferon-gamma level, decreased circulating interleukin-2 level, decreased interferon-alpha secretion, decreased interferon-beta secretion, decreased interferon-gamma secretion, decreased susceptibility to experimental autoimmune encephalomyelitis, decreased susceptibility to induced arthritis, hematopoietic system phenotype, immune system phenotype, impaired natural killer cell mediated cytotoxicity, increased B-1 B cell number, increased CD4-positive, alpha beta T cell number, increased T-helper 2 cell number, increased circulating interferon-gamma level, increased circulating interleukin-13 level, increased circulating interleukin-3 level, increased circulating interleukin-4 level, increased circulating interleukin-5 level, increased circulating interleukin-6 level, increased double-positive T cell number, increased incidence of tumors by chemical induction, increased lymphoma incidence, increased sensitivity to xenobiotic induced morbidity/mortality, increased susceptibility to Herpesvirales infection, increased susceptibility to Poxviridae infection, no abnormal phenotype detected, skeleton phenotype [+]
View all ortholog results at Monarch