pdss2 Phenotypes

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Phenotypes

Gene Literature (1)

Nucleotides (65)

Interactants (204)

XB-GENEPAGE-945062

Gene Symbol: pdss2 Gene Name: decaprenyl diphosphate synthase subunit 2

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal anterior-posterior axis, curved dorsal (1 source), abnormal development of embryo (1 source), abnormal gastrulation (1 source), decreased length of anterior-posterior axis (1 source), decreased length of tail (1 source)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + pdss2 MO (2 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (27 sources): Bilateral tonic-clonic seizure with focal onset, Cardiomegaly, Cerebral visual impairment, Developmental regression, EEG with focal spikes, Edema, Episodic vomiting, Feeding difficulties, Focal T2 hyperintense basal ganglia lesion, Gastrostomy tube feeding in infancy, Generalized edema, Heavy proteinuria, Hypoalbuminemia, Increased circulating lactate concentration, Infantile muscular hypotonia, Intrauterine growth retardation, Moderate albuminuria, Neonatal hypotonia, Nephrotic syndrome, Oligohydramnios, Proteinuria, Renal cyst, Renal tubular acidosis, Severe lactic acidosis, Status epilepticus, Tubulointerstitial nephritis, Undetectable visual evoked potentials [+]
Mouse (48 sources): abnormal Purkinje cell migration, abnormal aerobic respiration, abnormal cell morphology, abnormal cellular respiration, abnormal cerebellar foliation, abnormal cerebellum development, abnormal circulating cholesterol level, abnormal embryonic/fetal subventricular zone morphology, abnormal energy homeostasis, abnormal enzyme/coenzyme level, abnormal glomerular capsule parietal layer morphology, abnormal kidney morphology, abnormal mitochondrial ATP synthesis coupled electron transport, abnormal mitophagy, abnormal palatine bone horizontal plate morphology, abnormal podocyte morphology, abnormal radial glial cell morphology, abnormal renal glomerulus basement membrane morphology, abnormal renal glomerulus morphology, abnormal renal tubule morphology, abnormal respiratory electron transport chain, abnormal skeletal muscle morphology, absent Purkinje cell layer, absent gastric milk in neonates, colorless urine, decreased midbrain size, decreased mitochondrial DNA content, decreased radial glial cell number, dilated renal tubules, embryonic lethality during organogenesis, complete penetrance, embryonic lethality prior to organogenesis, embryonic lethality prior to tooth bud stage, granular kidney, homeostasis/metabolism phenotype, hunched posture, increased mitochondrial DNA content, increased neuron apoptosis, midbrain hypoplasia, oxidative stress, pale kidney, podocyte foot process effacement, postnatal lethality, complete penetrance, premature death, preweaning lethality, complete penetrance, renal cast, renal/urinary system phenotype, short mandible, small cerebellum [+]
View all ortholog results at Monarch