Monarch Ortholog Phenotypes
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Mouse (37 sources):
abnormal enterocyte morphology,
abnormal enterocyte proliferation,
abnormal epidermis stratum basale morphology,
abnormal epidermis stratum granulosum morphology,
abnormal hepatocyte morphology,
abnormal intestinal enteroendocrine cell morphology,
abnormal intestinal goblet cell morphology,
abnormal keratinocyte differentiation,
abnormal large intestine crypts of Lieberkuhn morphology,
abnormal lung development,
abnormal oval cell morphology,
abnormal oval cell physiology,
abnormal placental labyrinth vasculature morphology,
abnormal portal lobule morphology,
abnormal small intestinal microvillus morphology,
abnormal small intestine crypts of Lieberkuhn morphology,
colon polyps,
decreased survivor rate,
disorganized suprabasal layer,
epidermal hyperplasia,
fetal growth retardation,
impaired skin barrier function,
increased enterocyte cell number,
increased hepatocellular carcinoma incidence,
increased hepatocyte proliferation,
increased hepatoma incidence,
increased liver adenoma incidence,
increased liver tumor incidence,
increased liver weight,
increased lymphoma incidence,
lethality throughout fetal growth and development, incomplete penetrance,
liver/biliary system phenotype,
lung epithelium hyperplasia,
premature death,
prenatal lethality, complete penetrance,
retina hyperplasia,
underdeveloped hair follicles
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