| Monarch Ortholog Phenotypes
|
Human (29 sources):
Abnormality of the liver,
Anal atresia,
Arthralgia,
Autoimmune thrombocytopenia,
Brachycephaly,
Bronchiectasis,
Chronic otitis media,
Decreased circulating antibody level,
Elevated circulating hepatic transaminase concentration,
Emphysema,
Failure to thrive in infancy,
Gastrointestinal stroma tumor,
Glomerulonephritis,
Hemolytic anemia,
Immunodeficiency,
Lymphadenopathy,
Lymphoma,
Lymphopenia,
Otitis media,
Pneumonia,
Posterior pharyngeal cleft,
Purpura,
Recurrent bacterial infections,
Recurrent bronchitis,
Recurrent respiratory infections,
Restrictive ventilatory defect,
Splenomegaly,
Thrombocytopenia,
Vasculitis
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|
Mouse (23 sources):
abnormal CNS glial cell morphology,
abnormal T cell proliferation,
abnormal T-helper 2 physiology,
abnormal hippocampus CA1 region morphology,
abnormal hippocampus pyramidal cell morphology,
abnormal macrophage physiology,
abnormal microglial cell morphology,
abnormal nucleus accumbens morphology,
decreased B cell proliferation,
decreased B-1 B cell number,
decreased B-1a cell number,
decreased IgG1 level,
decreased locomotor activity,
decreased susceptibility to parasitic infection,
decreased susceptibility to type I hypersensitivity reaction,
impaired behavioral response to cocaine,
increased B cell proliferation,
increased IgG3 level,
increased astrocyte number,
increased brain weight,
increased dopamine level,
increased hippocampus volume,
nervous system phenotype
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.