Monarch Ortholog Phenotypes
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Human (58 sources):
Abdominal distention,
Abdominal pain,
Abnormal urine potassium concentration,
Acidosis,
Adrenal calcification,
Adrenal insufficiency,
Anemia,
Arteriosclerosis,
Ascites,
Bone-marrow foam cells,
Cachexia,
Cirrhosis,
Cognitive impairment,
Coronary artery atherosclerosis,
Decreased liver function,
Dehydration,
Diarrhea,
Elevated circulating alkaline phosphatase concentration,
Elevated circulating hepatic transaminase concentration,
Esophageal varix,
Failure to thrive,
Fatal liver failure in infancy,
Feeding difficulties,
Fever,
Global developmental delay,
Growth delay,
Hepatic failure,
Hepatic fibrosis,
Hepatic steatosis,
Hepatomegaly,
Hepatosplenomegaly,
Hypercholesterolemia,
Hyperkalemia,
Hypernatriuria,
Hypersplenism,
Hypertriglyceridemia,
Hyponatremia,
Hypotension,
Hypovolemia,
Jaundice,
Malnutrition,
Microvesicular hepatic steatosis,
Nausea and vomiting,
Precocious atherosclerosis,
Primary adrenal insufficiency,
Protuberant abdomen,
Pruritus,
Psychomotor deterioration,
Pulmonary arterial hypertension,
Renal salt wasting,
Splenomegaly,
Steatorrhea,
Stroke,
Vacuolated lymphocytes,
Vomiting,
Weight loss,
Xanthelasma,
Xanthomatosis
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Mouse (47 sources):
abnormal Kupffer cell morphology,
abnormal alveolar macrophage morphology,
abnormal brown adipose tissue morphology,
abnormal carbohydrate metabolism,
abnormal choroid plexus morphology,
abnormal duodenum morphology,
abnormal hepatocyte morphology,
abnormal inguinal fat pad morphology,
abnormal interscapular fat pad morphology,
abnormal intestinal mucosa morphology,
abnormal jejunum morphology,
abnormal lipid level,
abnormal lipid oxidation,
abnormal liver sinusoid morphology,
abnormal pulmonary alveolus morphology,
abnormal retroperitoneal fat pad morphology,
abnormal type II pneumocyte morphology,
abnormal white fat cell size,
adipose tissue phenotype,
chronic inflammation,
decreased brown adipose tissue amount,
decreased epididymal fat pad weight,
decreased gonadal fat pad weight,
decreased liver triglyceride level,
decreased susceptibility to diet-induced obesity,
decreased triglyceride lipase activity,
decreased unsaturated fatty acids level,
decreased white adipose tissue amount,
enlarged mesenteric lymph nodes,
improved glucose tolerance,
increased brown fat cell lipid droplet size,
increased circulating alanine transaminase level,
increased circulating aspartate transaminase level,
increased circulating ketone body level,
increased club cell number,
increased food intake,
increased insulin sensitivity,
increased liver cholesterol level,
increased liver triglyceride level,
increased liver weight,
increased respiratory quotient,
increased spleen weight,
increased type II pneumocyte number,
increased unsaturated fatty acids level,
pale kidney,
pale liver,
premature death
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View all ortholog results at Monarch
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