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XB-GENEPAGE-954419
letm1 leucine zipper-EF-hand containing transmembrane protein 1
Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology
covering anatomical, gene ontology, and neurobehavioral phenotypes.
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| decreased size of the head (2 sources), abnormal chondrocranium morphology (1 source), abnormal craniofacial region morphology (1 source) |
| Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.
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| Computed annotations: letm1 assayed (2 sources) |
| Diseases
Diseases from the human disease ontology (DO) manually associated with phenotypes
from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
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| Wolf-Hirschhorn syndrome (2AP sources) |
| Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting
the gene of interest.
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| Xla Wt + letm1 MO (2 sources) |
| Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
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| Mouse (10 sources): abnormal embryo development, abnormal mitochondrial physiology, craniofacial phenotype, decreased embryo size, decreased heart weight, decreased oxygen consumption, embryonic growth retardation, embryonic lethality during organogenesis, incomplete penetrance, embryonic lethality, complete penetrance, increased susceptibility to pharmacologically induced seizures |