Monarch Ortholog Phenotypes
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Human (28 sources):
Ataxia,
Babinski sign,
Brain atrophy,
Cerebellar atrophy,
Cerebellar vermis atrophy,
Cognitive impairment,
Difficulty walking,
Dysarthria,
Dysdiadochokinesis,
Dysmetria,
Esotropia,
Flexion contracture,
Functional motor deficit,
Gait ataxia,
Gaze-evoked nystagmus,
Generalized hypotonia,
Global developmental delay,
Horizontal nystagmus,
Hyperreflexia,
Hypotonia,
Incoordination,
Limb ataxia,
Neurological speech impairment,
Nystagmus,
Oculomotor apraxia,
Optic disc pallor,
Poor speech,
Truncal ataxia
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Mouse (78 sources):
Purkinje cell degeneration,
abnormal CNS synapse formation,
abnormal CNS synaptic transmission,
abnormal GABA-mediated receptor currents,
abnormal Purkinje cell dendrite morphology,
abnormal Purkinje cell innervation,
abnormal Purkinje cell morphology,
abnormal action potential,
abnormal autophagy,
abnormal cerebellar Purkinje cell layer,
abnormal cerebellar cortex morphology,
abnormal cerebellar foliation,
abnormal cerebellar granule layer morphology,
abnormal cerebellar molecular layer,
abnormal cerebellum development,
abnormal cerebellum lobule morphology,
abnormal cochlear VIII nucleus morphology,
abnormal discrimination learning,
abnormal excitatory postsynaptic currents,
abnormal eye blink conditioning behavior,
abnormal fertility/fecundity,
abnormal grooming behavior,
abnormal locomotor activation,
abnormal locomotor coordination,
abnormal miniature inhibitory postsynaptic currents,
abnormal motor capabilities/coordination/movement,
abnormal motor learning,
abnormal optokinetic reflex,
abnormal response to injury,
abnormal resting posture,
abnormal sensory capabilities/reflexes/nociception,
abnormal sexual interaction,
abnormal spatial learning,
abnormal sperm flagellum morphology,
abnormal suckling behavior,
abnormal synapse morphology,
abnormal synaptic neurotransmitter level,
abnormal trigeminal motor nucleus morphology,
absent gastric milk in neonates,
absent long term depression,
behavior/neurological phenotype,
decreased Purkinje cell number,
decreased birth weight,
decreased body size,
decreased cerebellar granule cell number,
decreased exploration in new environment,
decreased locomotor activity,
decreased survivor rate,
decreased vertical activity,
head tilt,
hindlimb paralysis,
hypoxia,
impaired balance,
impaired fertilization,
impaired limb coordination,
impaired righting response,
impaired sperm penetration of zona pellucida,
increased or absent threshold for auditory brainstem response,
increased prepulse inhibition,
lethality at weaning, complete penetrance,
limb grasping,
neonatal lethality, complete penetrance,
neonatal lethality, incomplete penetrance,
nervous system phenotype,
postnatal lethality,
reduced cerebellar foliation,
reduced female fertility,
reduced linear vestibular evoked potential,
reduced long term depression,
reduced male fertility,
reproductive system phenotype,
retropulsion,
short stride length,
small cerebellum,
thin cerebellar molecular layer,
thin external granule cell layer,
vision/eye phenotype,
weaving
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View all ortholog results at Monarch
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