mre11 Phenotypes

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Phenotypes

Gene Literature (54)

Nucleotides (99)

Interactants (275)

XB-GENEPAGE-957955

Gene Symbol: mre11 Gene Name: MRE11 homolog, double strand break repair nuclease

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (47 sources): Abnormality of chromosome stability, Abnormality of ocular smooth pursuit, Absent Achilles reflex, Ataxia, Cerebellar atrophy, Cerebellar vermis hypoplasia, Chorea, Chromosomal breakage induced by ionizing radiation, Delayed speech and language development, Dilated fourth ventricle, Distal amyotrophy, Drooling, Dysarthria, Dysdiadochokinesis, Dysmetria, Dysmetric saccades, Dystonia, Enlarged interhemispheric fissure, Frequent falls, Gait ataxia, Gaze-evoked nystagmus, Generalized hypotonia, Hyperactive deep tendon reflexes, Hypergonadotropic hypogonadism, Hypermetropia, Hypometric saccades, Hyporeflexia, Impaired smooth pursuit, Increased sensitivity to ionizing radiation, Intellectual disability, Intention tremor, Lower limb spasticity, Mask-like facies, Microcephaly, Myoclonus, obsolete Joint laxity, Oculomotor apraxia, Orofacial dyskinesia, Pes cavus, Reduced tendon reflexes, Sensorimotor neuropathy, Short stature, Slow saccadic eye movements, Small posterior fossa, Spasticity, Telangiectasia, Vertical nystagmus [+]
Mouse (19 sources): abnormal cell cycle checkpoint function, abnormal class switch recombination, abnormal embryo development, abnormal heart development, cellular phenotype, chromosomal instability, decreased cell proliferation, decreased cellular sensitivity to ionizing radiation, embryonic growth arrest, embryonic lethality, complete penetrance, embryonic lethality during organogenesis, complete penetrance, increased cellular sensitivity to ionizing radiation, increased mitotic index, increased mortality induced by gamma-irradiation, induced chromosome breakage, maternal effect, reduced female fertility, reproductive system phenotype, spontaneous chromosome breakage [+]
View all ortholog results at Monarch