tph2 Phenotypes

Phenotypes

XB-GENEPAGE-958328

Gene Symbol: tph2 Gene Name: tryptophan hydroxylase 2

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: tph2 assayed (4 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (33 sources): abnormal circadian regulation of heart rate, abnormal circadian regulation of systemic arterial blood pressure, abnormal maternal nurturing, abnormal mating preference, abnormal paraventricular hypothalamic nucleus morphology, abnormal pup retrieval, abnormal response to novel object, abnormal serotonergic neuron morphology, abnormal serotonin level, abnormal skin condition, abnormal sleep pattern, abnormal suprachiasmatic nucleus morphology, behavior/neurological phenotype, decreased body length, decreased body size, decreased circulating insulin-like growth factor I level, decreased coping response, decreased pulmonary respiratory rate, decreased serotonin level, impaired adaptive thermogenesis, increased aggression, increased aggression towards female mice, increased aggression towards male mice, increased anxiety-related response, increased core body temperature, induced hyperactivity, nervous system phenotype, no abnormal phenotype detected, postnatal lethality, incomplete penetrance, premature death, pup cannibalization, taste/olfaction phenotype, weakness [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (33 sources): abnormal circadian regulation of heart rate, abnormal circadian regulation of systemic arterial blood pressure, abnormal maternal nurturing, abnormal mating preference, abnormal paraventricular hypothalamic nucleus morphology, abnormal pup retrieval, abnormal response to novel object, abnormal serotonergic neuron morphology, abnormal serotonin level, abnormal skin condition, [+]