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Summary Expression Phenotypes Gene Literature (3) GO Terms (32) Nucleotides (241) Proteins (107) Interactants (262) Wiki
XB-GENEPAGE-959256

dnm2     dynamin 2

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal tracheoesophageal septum (3 sources), abnormal esophagus morphology (1 source), abnormally localised mitotic spindle (1 source), abnormal trachea morphology (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: dnm2 manipulated (2 sources)
Diseases
Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
esophageal atresia/tracheoesophageal fistula (3AP sources, 2 EP sources), esophageal atresia (2AP sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + dnm2 CRISPR (4 sources)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (58 sources): Abnormality of the foot musculature, Areflexia, Areflexia of lower limbs, Axonal degeneration, Calf muscle hypertrophy, Cavernous hemangioma, Centrally nucleated skeletal muscle fibers, Congenital contracture, Cryptorchidism, Decreased fetal movement, [+]
Mouse (33 sources): abnormal action potential, abnormal calcium ion homeostasis, abnormal embryo size, abnormal mean corpuscular hemoglobin, abnormal muscle contractility, abnormal muscle electrophysiology, abnormal neuromuscular synapse morphology, abnormal skeletal muscle fiber type ratio, aorta hypoplasia, behavior/neurological phenotype, [+]

View all ortholog results at Monarch