| Monarch Ortholog Phenotypes
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Human (43 sources):
Abnormality of neutrophils,
Absence of bactericidal oxidative respiratory burst in phagocytes,
Cellulitis,
Chronic pulmonary obstruction,
Cutaneous photosensitivity,
Decreased activity of NADPH oxidase,
Deficiency or absence of cytochrome b(-245),
Discoid lupus rash,
Eczematoid dermatitis,
Fever,
Gingivitis,
Granulomatosis,
Hepatomegaly,
Hypermelanotic macule,
Immunodeficiency,
Impaired oxidative burst,
Inflammatory abnormality of the eye,
Liver abscess,
Lymphadenitis,
Lymphadenopathy,
Macule,
Malabsorption,
Mediastinal lymphadenopathy,
Meningitis,
Osteomyelitis,
Otitis media,
Pyloric stenosis,
Rectal abscess,
Recurrent Aspergillus infections,
Recurrent Burkholderia cepacia infections,
Recurrent E. coli infections,
Recurrent Klebsiella infections,
Recurrent Serratia marcescens infections,
Recurrent Staphylococcus aureus infections,
Recurrent bacterial skin infections,
Recurrent pneumonia,
Recurrent respiratory infections,
Sepsis,
Sinusitis,
Skin ulcer,
Splenomegaly,
Tracheoesophageal fistula,
obsolete Eczematoid dermatitis
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Mouse (21 sources):
abnormal T cell activation,
abnormal intestinal goblet cell physiology,
abnormal redox activity,
abnormal sympathetic nervous system physiology,
abnormal systemic arterial blood pressure,
abnormal systemic arterial blood pressure regulation,
absent linear vestibular evoked potential,
absent otoliths,
decreased blood urea nitrogen level,
decreased circulating amylase level,
decreased heart rate variability,
decreased mean systemic arterial blood pressure,
head tilt,
hearing/vestibular/ear phenotype,
impaired balance,
impaired righting response,
impaired swimming,
increased bone mineral content,
increased lean body mass,
persistence of hyaloid vascular system,
trunk curl
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.