| Monarch Ortholog Phenotypes
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Human (28 sources):
Abnormal bleeding,
Abnormal fingernail morphology,
Abnormal megakaryocyte morphology,
Abnormal number of granulocyte precursors,
Acute myeloid leukemia,
Anemia of inadequate production,
Bone marrow hypocellularity,
Chronic infection,
Congestive heart failure,
Dysplastic granulopoesis,
Erythroid hyperplasia,
Granulocytopenia,
Hepatomegaly,
Hypochromic anemia,
Hyposegmentation of neutrophil nuclei,
Increased megakaryocyte count,
Leukocytosis,
Megaloblastic erythroid hyperplasia,
Myelodysplasia,
Neutropenia,
Normochromic anemia,
Normocytic anemia,
Pallor,
Pancytopenia,
Refractory anemia with ringed sideroblasts,
Splenomegaly,
Thrombocytopenia,
Thrombocytosis
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Mouse (15 sources):
abnormal erythroid progenitor cell morphology,
abnormal erythropoiesis,
abnormal myelopoiesis,
cervical vertebral transformation,
decreased erythrocyte cell number,
decreased granulocyte monocyte progenitor cell number,
embryonic lethality before implantation, complete penetrance,
hypochromic macrocytic anemia,
impaired hematopoiesis,
increased circulating erythropoietin level,
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.