| Monarch Ortholog Phenotypes
|
Human (53 sources):
2-3 toe syndactyly,
Aggressive behavior,
Agitation,
Anteverted nares,
Anxiety,
Attention deficit hyperactivity disorder,
Autistic behavior,
Babinski sign,
Bilateral tonic-clonic seizure,
Broad nasal tip,
Clinodactyly of the 2nd toe,
Delayed eruption of teeth,
Delayed gross motor development,
Delayed speech and language development,
Depressed nasal bridge,
Downslanted palpebral fissures,
Drooling,
Facial palsy,
Flat face,
Generalized non-motor (absence) seizure,
Global developmental delay,
High palate,
Hyperactivity,
Intellectual disability,
Intellectual disability, moderate,
Intellectual disability, profound,
Intellectual disability, severe,
Long palpebral fissure,
Long philtrum,
Macrocephaly,
Macrotia,
Meckel diverticulum,
Microcephaly,
Midface retrusion,
Mild neurosensory hearing impairment,
Moderate sensorineural hearing impairment,
Obesity,
Open mouth,
Periorbital fullness,
Pes planus,
Poor speech,
Psychosis,
Pyloric stenosis,
Restlessness,
Seizure,
Short attention span,
Short nose,
Shortening of all distal phalanges of the fingers,
Small for gestational age,
Thick lower lip vermilion,
Thin upper lip vermilion,
Urinary incontinence,
Widened subarachnoid space
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Mouse (15 sources):
abnormal conditioned taste aversion behavior,
abnormal dendritic spine morphology,
abnormal dentate gyrus neuron dendrite morphology,
abnormal learning/memory/conditioning,
abnormal long term spatial reference memory,
abnormal miniature excitatory postsynaptic currents,
abnormal neuron differentiation,
abnormal neuron physiology,
abnormal synapse morphology,
abnormal synaptic vesicle number,
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.