| Monarch Ortholog Phenotypes
|
Human (23 sources):
Abnormal respiratory system physiology,
Agitation,
Amyotrophic lateral sclerosis,
Anxiety,
Degeneration of anterior horn cells,
Depression,
Dyspnea,
Emotional lability,
Fatigable weakness of bulbar muscles,
Fatigable weakness of respiratory muscles,
Fatigable weakness of swallowing muscles,
Fatigue,
Generalized muscle weakness,
Laryngospasm,
Muscle spasm,
Nausea and vomiting,
Neurodegeneration,
Pain,
Paralysis,
Respiratory insufficiency,
Skeletal muscle atrophy,
Spasticity,
Xerostomia
[+]
|
Mouse (21 sources):
abnormal allantois morphology,
abnormal hindbrain development,
abnormal placenta development,
abnormal rostral-caudal axis patterning,
abnormal visceral yolk sac morphology,
abnormal vitelline vascular remodeling,
abnormal vitelline vasculature morphology,
absent vitelline blood vessels,
decreased cell proliferation,
decreased embryo size,
delayed brain development,
digestive/alimentary phenotype,
disorganized yolk sac vascular plexus,
embryonic lethality during organogenesis, complete penetrance,
failure of chorioallantoic fusion,
forebrain hypoplasia,
incomplete embryo turning,
kinked neural tube,
midbrain hypoplasia,
skeleton phenotype,
small hindlimb buds
[+]
|
View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.