| Monarch Ortholog Phenotypes
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Human (26 sources):
Abnormal bleeding,
Decreased glomerular filtration rate,
Decreased muscle mass,
Delayed puberty,
Doll-like facies,
Elevated circulating hepatic transaminase concentration,
Enlarged kidney,
Focal segmental glomerulosclerosis,
Gout,
Hepatocellular carcinoma,
Hepatomegaly,
Hyperlipidemia,
Hypertension,
Hyperuricemia,
Hypoglycemia,
Intermittent diarrhea,
Lactic acidosis,
Lipemia retinalis,
Nephrolithiasis,
Osteoporosis,
Pancreatitis,
Proteinuria,
Protuberant abdomen,
Short stature,
Xanthelasma,
Xanthomatosis
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Mouse (21 sources):
abnormal blood homeostasis,
abnormal cartilage development,
abnormal hepatocyte morphology,
abnormal kidney morphology,
abnormal lipid homeostasis,
abnormal long bone epiphyseal plate morphology,
abnormal podocyte morphology,
abnormal renal tubule epithelium morphology,
abnormal renal tubule morphology,
decreased circulating glucose level,
decreased urine pH,
dilated renal tubules,
homeostasis/metabolism phenotype,
increased kidney glycogen level,
increased kidney weight,
increased liver adenoma incidence,
increased liver triglyceride level,
increased liver weight,
pale liver,
premature death,
renal glomerulus atrophy
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.