fah Phenotypes

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Phenotypes

Gene Literature (0)

Nucleotides (116)

Interactants (9)

XB-GENEPAGE-964391

Gene Symbol: fah Gene Name: fumarylacetoacetate hydrolase (fumarylacetoacetase)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: fah assayed (7 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (30 sources): Abnormal bleeding, Abnormality of coagulation, Abnormality of the abdominal wall, Acute hepatic failure, Ascites, Cirrhosis, Elevated circulating alpha-fetoprotein concentration, Elevated circulating hepatic transaminase concentration, Elevated urinary delta-aminolevulinic acid, Enlarged kidney, Episodic peripheral neuropathy, Failure to thrive, Gastrointestinal hemorrhage, Generalized aminoaciduria, Glomerular sclerosis, Hepatocellular carcinoma, Hepatomegaly, Hypermethioninemia, Hypertrophic cardiomyopathy, Hypertyrosinemia, Hypoglycemia, Hypophosphatemic rickets, Nephrocalcinosis, Pancreatic islet-cell hyperplasia, Paralytic ileus, Periodic paralysis, Renal Fanconi syndrome, Renal insufficiency, Rickets of the lower limbs, Splenomegaly [+]
Mouse (28 sources): abnormal amino acid level, abnormal circulating aspartate transaminase level, abnormal hepatocyte morphology, abnormal hepatocyte physiology, abnormal liver lobule morphology, abnormal liver regeneration, abnormal sleep pattern, decreased hepatocyte apoptosis, decreased hepatocyte proliferation, dilated renal tubules, impaired liver regeneration, increased circulating aspartate transaminase level, increased circulating creatinine level, increased hepatocellular carcinoma incidence, increased hepatoma incidence, increased liver adenoma incidence, increased liver tumor incidence, increased pancreatic alpha cell number, increased sensitivity to induced morbidity/mortality, increased sensitivity to xenobiotic induced morbidity/mortality, increased susceptibility to injury, kidney degeneration, liver/biliary system phenotype, neonatal lethality, complete penetrance, pale kidney, pale liver, postnatal lethality, complete penetrance, preweaning lethality, complete penetrance [+]
View all ortholog results at Monarch