pak1 Phenotypes

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Phenotypes

Gene Literature (60)

Nucleotides (124)

Interactants (382)

XB-GENEPAGE-967715

Gene Symbol: pak1 Gene Name: p21 protein (Cdc42/Rac)-activated kinase 1

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: pak1 assayed (2 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (22 sources): Broad forehead, Deeply set eye, Delayed ability to walk, Delayed myelination, Delayed speech and language development, Esodeviation, Frontal bossing, Gait ataxia, Gastroesophageal reflux, Generalized hypotonia, Global developmental delay, Intellectual disability, severe, Long face, Microtia, Motor delay, Periventricular white matter hyperintensities, Poor speech, Postnatal macrocephaly, Receptive language delay, Recurrent hypoglycemia, Seizure, Unsteady gait [+]
Mouse (15 sources): abnormal blood urea nitrogen level, cardiac fibrosis, cardiac hypertrophy, decreased bone mineral content, decreased cardiac muscle contractility, decreased mast cell degranulation, enlarged myocardial fiber, hematopoietic system phenotype, increased cardiomyocyte apoptosis, increased heart weight, increased response of heart to induced stress, increased total body fat amount, nervous system phenotype, no abnormal phenotype detected, reduced long term potentiation [+]
View all ortholog results at Monarch