lama1 Phenotypes

Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Phenotypes

Gene Literature (17)

Nucleotides (165)

Interactants (195)

XB-GENEPAGE-968307

Gene Symbol: lama1 Gene Name: laminin subunit alpha 1

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: lama1 assayed (6 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (19 sources): Abnormal periventricular white matter morphology, Amblyopia, Cerebellar cyst, Cerebellar dysplasia, Cerebellar vermis hypoplasia, Delayed speech and language development, Dilated fourth ventricle, Generalized hypotonia, Gray matter heterotopia, Hypotonia, Ischemic stroke, Motor delay, Myopia, Nystagmus, Oculomotor apraxia, Retinal atrophy, Retinal dystrophy, Retinal thinning, Strabismus [+]
Mouse (43 sources): abnormal Bergmann glial cell morphology, abnormal Muller cell morphology, abnormal Purkinje cell dendrite morphology, abnormal Reichert's membrane morphology, abnormal brain meninges morphology, abnormal brain pia mater morphology, abnormal cerebellar Purkinje cell layer, abnormal cerebellar foliation, abnormal cerebellar granule layer morphology, abnormal ectoplacental cone morphology, abnormal eye electrophysiology, abnormal gastrulation, abnormal parietal endoderm morphology, abnormal radial glial cell morphology, abnormal retina blood vessel morphology, abnormal retina blood vessel pattern, abnormal retina inner limiting membrane morphology, abnormal retina neuronal layer morphology, abnormal retina vasculature morphology, abnormal visceral endoderm morphology, abnormal vitreous body morphology, absent Reichert's membrane, absent blastocoele, decreased birth weight, decreased embryo size, decreased retina inner nuclear layer thickness, embryonic growth retardation, embryonic lethality between implantation and somite formation, complete penetrance, increased embryonic tissue cell apoptosis, increased lean body mass, increased startle reflex, limb grasping, no abnormal phenotype detected, persistence of hyaloid vascular system, preweaning lethality, complete penetrance, reproductive system phenotype, retina outer nuclear layer degeneration, retina spots, short stride length, small cerebellum, thin retina ganglion layer, thin retina inner plexiform layer, vitreal fibroplasia [+]
View all ortholog results at Monarch