| Monarch Ortholog Phenotypes
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Human (11 sources):
Areflexia,
Decreased fetal movement,
Flexion contracture,
Generalized muscle weakness,
High palate,
Motor delay,
Myopathic facies,
Neck muscle weakness,
Respiratory insufficiency due to muscle weakness,
Severe muscular hypotonia,
[+]
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Mouse (9 sources):
abnormal extraembryonic endoderm formation,
abnormal visceral yolk sac cavity morphology,
absent mesoderm,
decreased embryo size,
decreased survivor rate,
embryonic growth arrest,
embryonic lethality between somite formation and embryo turning, incomplete penetrance,
failure of primitive streak formation,
no abnormal phenotype detected
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.