fto Phenotypes

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Phenotypes

Gene Literature (1)

Nucleotides (132)

Interactants (69)

XB-GENEPAGE-972563

Gene Symbol: fto Gene Name: FTO alpha-ketoglutarate dependent dioxygenase

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal development of left-right axis (4 sources), abnormally decreased number of cilium in the multiciliated cell (3 sources), abnormal determination of left/right symmetry in alimentary system (2 sources), abnormal heart looping (2 sources), obsolete decreased length of cilium in gastrocoel roof plate (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: fto manipulated (5 sources)
Computed annotations: fto assayed (2 sources)

Diseases Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
situs inversus (11AP sources, 5 EP sources), visceral heterotaxy (11AP sources, 5 EP sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + fto MO (14 sources), Xla Wt + fto MO + actinomycin D + animal cap explant (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (29 sources): Anteverted nares, Bifid uvula, Brachydactyly, Cleft palate, Coarse facial features, Cryptorchidism, Cutis marmorata, Dandy-Walker malformation, Failure to thrive, Global developmental delay, Hydrocephalus, Hypertrophic cardiomyopathy, Intrauterine growth retardation, Lissencephaly, Macroglossia, Microcephaly, Moderate albuminuria, Obesity, Patent ductus arteriosus, Protruding tongue, Retrognathia, Seizure, Sensorineural hearing impairment, Short neck, Skull asymmetry, Small nail, Spasticity, Umbilical hernia, Ventricular septal defect [+]
Mouse (38 sources): abnormal carbon dioxide production, abnormal circulating lipid level, abnormal hormone level, abnormal oxygen consumption, decreased body length, decreased carbon dioxide production, decreased circulating alanine transaminase level, decreased circulating aspartate transaminase level, decreased circulating insulin-like growth factor I level, decreased circulating iron level, decreased food intake, decreased gonadal fat pad weight, decreased lactate dehydrogenase level, decreased lean body mass, decreased locomotor activity, decreased percent body fat/body weight, decreased respiratory quotient, decreased susceptibility to diet-induced obesity, decreased white fat cell size, dermatitis, growth/size/body region phenotype, homeostasis/metabolism phenotype, improved glucose tolerance, increased abdominal fat pad weight, increased basal metabolism, increased carbon dioxide production, increased circulating adrenaline level, increased circulating glucose level, increased energy expenditure, increased food intake, increased lean body mass, increased oxygen consumption, increased respiratory quotient, increased susceptibility to diet-induced obesity, increased total body fat amount, postnatal lethality, incomplete penetrance, premature death, preweaning lethality, incomplete penetrance [+]
View all ortholog results at Monarch