crbn Phenotypes

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Phenotypes

Gene Literature (0)

Nucleotides (336)

Interactants (22)

XB-GENEPAGE-973906

Gene Symbol: crbn Gene Name: cereblon

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: crbn assayed (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (39 sources): Abnormal facial shape, Absent septum pellucidum, Attention deficit hyperactivity disorder, Autistic behavior, Cerebral atrophy, Cerebral visual impairment, Chorea, Cortical dysplasia, Delayed speech and language development, Depression, Dyskinesia, Dystonia, EEG with focal epileptiform discharges, EEG with generalized epileptiform discharges, Epileptic spasm, Focal-onset seizure, Generalized hypotonia, Generalized-onset seizure, Global developmental delay, Hyperactivity, Hypoplasia of the corpus callosum, Hypotonia, Hypsarrhythmia, Impulsivity, Intellectual disability, mild, Intellectual disability, moderate, Intellectual disability, severe, Large basal ganglia, Microcephaly, Motor delay, Motor stereotypy, Multifocal epileptiform discharges, Nasogastric tube feeding, Polymicrogyria, Poor speech, Seizure, Short attention span, Sleep abnormality, Spasticity [+]
Mouse (26 sources): abnormal bone marrow hematopoietic cell morphology, abnormal cecum morphology, abnormal long term spatial reference memory, abnormal seminal vesicle morphology, abnormal synapse morphology, behavior/neurological phenotype, decreased circulating free fatty acids level, decreased circulating glucose level, decreased common myeloid progenitor cell number, decreased epididymal fat pad weight, decreased granulocyte monocyte progenitor cell number, decreased granulocyte number, decreased liver triglyceride level, decreased liver weight, decreased startle reflex, decreased susceptibility to diet-induced obesity, decreased susceptibility to hepatic steatosis, impaired contextual conditioning behavior, impaired spatial learning, improved glucose tolerance, increased insulin sensitivity, increased physiological sensitivity to xenobiotic, nervous system phenotype, prenatal lethality, incomplete penetrance, reduced long term potentiation, small liver [+]
View all ortholog results at Monarch