Monarch Ortholog Phenotypes
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Human (69 sources):
Abnormal aortic morphology,
Abnormal cardiovascular system morphology,
Abnormal lung lobation,
Abnormal skull morphology,
Abnormality of immune system physiology,
Abnormality of skin pigmentation,
Abnormality of the orbital region,
Abnormality of the skeletal system,
Abnormality of the upper limb,
Abnormality of vision,
Acute lymphoblastic leukemia,
Ambiguous genitalia,
Aortic regurgitation,
Aplasia/Hypoplasia of the cerebellum,
Aplasia/Hypoplasia of the corpus callosum,
Apnea,
Ascites,
Atrial septal defect,
Cataract,
Cleft palate,
Clinodactyly of the 5th finger,
Coarctation of aorta,
Colon cancer,
Corneal opacity,
Dandy-Walker malformation,
Depressed nasal ridge,
Downslanted palpebral fissures,
Duodenal atresia,
Epicanthus,
Frontal bossing,
Glaucoma,
Global developmental delay,
Growth delay,
Hearing impairment,
Hereditary nonpolyposis colorectal carcinoma,
High forehead,
Holoprosencephaly,
Hypothyroidism,
Hypotonia,
Increased nuchal translucency,
Intellectual disability,
Intestinal polyposis,
Intrauterine growth retardation,
Low-set, posteriorly rotated ears,
Microcephaly,
Micrognathia,
Microphthalmia,
Multicystic kidney dysplasia,
Multiple cafe-au-lait spots,
Muscular dystrophy,
Myelodysplasia,
Neoplasm,
Neoplasm of the stomach,
Nephroblastoma,
Osteolysis,
Polyhydramnios,
Renal cell carcinoma,
Rhabdomyosarcoma,
Seizure,
Short stature,
Sloping forehead,
Stomach cancer,
Subvalvular aortic stenosis,
Transitional cell carcinoma of the bladder,
Triangular face,
Uterine leiomyosarcoma,
Vaginal neoplasm,
Ventriculomegaly,
Wide nose
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Mouse (38 sources):
abnormal cell cycle checkpoint function,
abnormal cell death,
abnormal mitosis,
abnormal mitotic spindle assembly checkpoint,
abnormal mitotic spindle morphology,
abnormal startle reflex,
aneuploidy,
chromosomal instability,
decreased birth weight,
decreased cell proliferation,
decreased fetal size,
decreased fibroblast apoptosis,
decreased fibroblast proliferation,
decreased litter size,
decreased mitotic index,
decreased startle reflex,
decreased testis weight,
decreased tumor incidence,
decreased tumor latency,
early cellular replicative senescence,
embryonic lethality between implantation and somite formation, complete penetrance,
embryonic lethality during organogenesis, complete penetrance,
embryonic lethality prior to organogenesis,
embryonic lethality, complete penetrance,
fetal growth retardation,
increased hepatocellular carcinoma incidence,
increased incidence of induced tumors,
increased incidence of tumors by chemical induction,
increased liver tumor incidence,
increased lung tumor incidence,
increased lymphoma incidence,
maternal effect,
no abnormal phenotype detected,
pale liver,
perinatal lethality, incomplete penetrance,
preweaning lethality, complete penetrance,
reduced male fertility,
small seminiferous tubules
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View all ortholog results at Monarch
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