cybb Phenotypes

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Phenotypes

Gene Literature (2)

Nucleotides (133)

Interactants (11)

XB-GENEPAGE-978452

Gene Symbol: cybb Gene Name: cytochrome b-245, beta polypeptide

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: cybb assayed (6 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (45 sources): Abnormality of neutrophils, Absence of bactericidal oxidative respiratory burst in phagocytes, Cellulitis, Chronic pulmonary obstruction, Cutaneous photosensitivity, Decreased activity of NADPH oxidase, Deficiency or absence of cytochrome b(-245), Discoid lupus rash, Eczematoid dermatitis, Fever, Gingivitis, Granulomatosis, Hepatomegaly, Hypermelanotic macule, Immunodeficiency, Impaired oxidative burst, Inflammatory abnormality of the eye, Liver abscess, Lymphadenitis, Lymphadenopathy, Macule, Malabsorption, Mediastinal lymphadenopathy, Meningitis, Osteomyelitis, Otitis media, Pyloric stenosis, Rectal abscess, Recurrent Aspergillus infections, Recurrent Burkholderia cepacia infections, Recurrent E. coli infections, Recurrent Klebsiella infections, Recurrent Serratia marcescens infections, Recurrent Staphylococcus aureus infections, Recurrent bacterial skin infections, Recurrent mycobacterial infections, Recurrent pneumonia, Recurrent respiratory infections, Sepsis, Severe recurrent varicella, Sinusitis, Skin ulcer, Splenomegaly, Tracheoesophageal fistula, obsolete Eczematoid dermatitis [+]
Mouse (55 sources): abnormal aorta tunica media morphology, abnormal circulating chemokine level, abnormal cued conditioning behavior, abnormal intestinal mucosa morphology, abnormal kidney morphology, abnormal long term potentiation, abnormal macrophage chemotaxis, abnormal macrophage physiology, abnormal myocardial fiber morphology, abnormal nitric oxide homeostasis, abnormal renal glomerulus morphology, abnormal spatial learning, cardiac hypertrophy, cardiovascular system phenotype, decreased body length, decreased cholesterol level, decreased circulating interleukin-10 level, decreased fasting circulating glucose level, decreased fat cell size, decreased metastatic potential, decreased post-tetanic potentiation, decreased renal plasma flow rate, decreased renal vascular resistance, decreased right ventricle systolic pressure, decreased susceptibility to diet-induced obesity, decreased systemic arterial blood pressure, decreased systemic arterial systolic blood pressure, decreased triglyceride level, decreased tumor growth/size, decreased urine sodium level, decreased vertical activity, digestive/alimentary phenotype, granulomatous inflammation, homeostasis/metabolism phenotype, immune system phenotype, increased acute inflammation, increased anti-double stranded DNA antibody level, increased anti-nuclear antigen antibody level, increased autoantibody level, increased brain size, increased circulating creatinine level, increased circulating interleukin-1 beta level, increased circulating interleukin-12b level, increased circulating interleukin-6 level, increased epididymal fat pad weight, increased neutrophil cell number, increased renal glomerular filtration rate, increased renal plasma flow rate, increased spleen weight, increased susceptibility to systemic lupus erythematosus, increased urine creatinine level, increased urine nitrite level, increased urine sodium level, reduced long term potentiation, renal/urinary system phenotype [+]
View all ortholog results at Monarch