Diplopia, Distal muscle weakness, Dysarthria, Dysmyelinating leukodystrophy, Flexion contracture, Generalized limb muscle atrophy, Hearing impairment, Hyperreflexia, Hypoplasia of the corpus callosum, Hyporeflexia, Impaired distal proprioception, Impaired pursuit initiation and maintenance, Impaired vibration sensation in the lower limbs, Impaired visuospatial constructive cognition, Increased CSF lactate, Increased serum lactate, Intellectual disability, Leg muscle stiffness, Leukoencephalopathy, Mental deterioration, Motor delay, Muscle weakness, Muscular hypotonia, Neurological speech impairment, Nystagmus, Optic atrophy, Peripheral axonal neuropathy, Polyneuropathy, Poor fine motor coordination, Progressive cerebellar ataxia, Progressive inability to walk, Progressive spasticity, Ptosis, Reduced tendon reflexes, Seizure, Skeletal muscle atrophy, Slow saccadic eye movements, Slurred speech, Spastic ataxia, Spastic/hyperactive bladder, Spasticity, Specific learning disability, Tremor, Truncal ataxia, Unsteady gait, Upper motor neuron dysfunction