Hypergonadotropic hypogonadism, Hyperinsulinemia, Hypertriglyceridemia, Hypogonadism, Hypoplasia of the ovary, Insulin-resistant diabetes mellitus, Micropenis, Obesity, Orthostatic hypotension due to autonomic dysfunction, Pituitary hypothyroidism, Polyphagia, Primary amenorrhea, Recurrent ear infections, Recurrent pneumonia, Recurrent upper respiratory tract infections

abnormal cortical plate morphology, abnormal corticosterone level, abnormal embryonic neuroepithelium morphology, abnormal epididymal fat pad morphology, abnormal excitatory postsynaptic currents, abnormal eye posterior chamber depth, abnormal fasting circulating glucose level, abnormal fat cell morphology, abnormal food intake, abnormal frequency of paradoxical sleep, abnormal gland physiology, abnormal gonadal fat pad morphology, abnormal grip strength, abnormal heart weight, abnormal hepatocyte physiology, abnormal hormone level, abnormal inhibitory postsynaptic currents, abnormal insulin secretion, abnormal intestinal epithelium morphology, abnormal intestinal mucosa morphology, abnormal lipid level, abnormal liver weight, abnormal locomotor activation, abnormal long bone epiphyseal plate morphology, abnormal long bone epiphyseal plate proliferative zone, abnormal long bone hypertrophic chondrocyte zone, abnormal microglial cell physiology, abnormal muscle contractility, abnormal myocardial fiber morphology, abnormal myocardial fiber physiology, abnormal nucleotide metabolism, abnormal osteoclast differentiation, abnormal ovarian folliculogenesis, abnormal oxygen consumption, abnormal pain threshold, abnormal pancreatic beta cell morphology, abnormal pancreatic beta cell physiology, abnormal pancreatic islet morphology, abnormal podocyte morphology, abnormal postnatal growth, abnormal protein level, abnormal respiratory electron transport chain, abnormal response to cardiac infarction, abnormal retina inner nuclear layer morphology, abnormal retina vasculature morphology, abnormal skeletal muscle fiber type ratio, abnormal skeleton development, abnormal sleep pattern, abnormal startle reflex, abnormal sympathetic nervous system physiology, abnormal vagina orifice morphology, abnormal vascular wound healing, abnormal white adipose tissue morphology, absent corpus luteum, cardiovascular system phenotype, decreased CD4-positive, alpha beta T cell number, decreased T cell proliferation, decreased body length, decreased bone mass, decreased brown adipose tissue amount, decreased cardiac muscle contractility, decreased circulating free fatty acids level, decreased circulating glucose level, decreased circulating growth hormone level, decreased circulating prolactin level, decreased circulating tumor necrosis factor level, decreased embryonic neuroepithelial cell proliferation, decreased embryonic neuroepithelium thickness, decreased exploration in new environment, decreased food intake, decreased grip strength, decreased heart weight, decreased insulin secretion, decreased lean body mass, decreased liver glycogen level, decreased liver triglyceride level, decreased liver weight, decreased locomotor activity, decreased oxygen consumption, decreased pancreatic beta cell mass, decreased pituitary hormone level, decreased seminal vesicle weight, decreased skeletal muscle fiber size, decreased skeletal muscle mass, decreased somatotroph cell number, decreased splenocyte number, decreased susceptibility to hepatic steatosis, decreased testis weight, decreased total retina thickness, decreased vertical activity, decreased white adipose tissue amount, decreased white fat cell number, disorganized pancreatic islets, endocrine/exocrine gland phenotype, enlarged myocardial fiber, fragmentation of sleep/wake states, homeostasis/metabolism phenotype, hyperalgesia, hypersecretion of corticosterone, impaired adaptive thermogenesis, increased adrenocorticotropin level, increased body fat mass, increased body length, increased bone mass, increased brown adipose tissue amount, increased brown fat cell lipid droplet size, increased cardiac output, increased cardiac stroke volume, increased cholesterol level, increased circulating glucose level, increased defecation amount, increased fasting circulating glucose level, increased food intake, increased gonadal fat pad weight, increased growth rate, increased heart weight, increased hepatocyte apoptosis, increased inguinal fat pad weight, increased insulin secretion, increased insulin sensitivity, increased interleukin-6 secretion, increased interscapular fat pad weight, increased kidney weight, increased lean body mass, increased liver cholesterol level, increased liver triglyceride level, increased liver weight, increased macrophage cell number, increased metastatic potential, increased oxygen consumption, increased pancreas weight, increased pancreatic beta cell mass, increased pancreatic beta cell number, increased pancreatic islet number, increased percent body fat/body weight, increased pituitary hormone level, increased renal glomerulus basement membrane thickness, increased startle reflex, increased susceptibility to diet-induced obesity, increased susceptibility to endotoxin shock, increased thermal nociceptive threshold, increased total body fat amount, increased white adipose tissue amount, increased white fat cell number, increased white fat cell size, macrovesicular hepatic steatosis, nervous system phenotype, oxidative stress, pale liver, pancreatic islet hyperplasia, postnatal lethality, incomplete penetrance, premature death, prolonged QRS complex duration, prolonged RR interval, prolonged diestrus, prolonged estrous cycle, prolonged estrus, reduced male fertility, renal glomerulus hypertrophy, small liver, small pancreatic islets