lgals3 Phenotypes

Phenotypes

XB-GENEPAGE-983742

Gene Symbol: lgals3 Gene Name: lectin, galactoside-binding, soluble, 3

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: lgals3 assayed (5 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (37 sources): Mallory bodies, abnormal CD8-positive, alpha-beta cytotoxic T cell morphology, abnormal circadian behavior, abnormal dendritic cell physiology, abnormal hepatocyte morphology, abnormal leukocyte physiology, abnormal long bone epiphyseal plate morphology, abnormal long bone hypertrophic chondrocyte zone, abnormal macrophage physiology, abnormal monocyte morphology, abnormal response to infection, aggression towards inanimate objects, decreased granulocyte number, decreased locomotor activity, decreased macrophage cell number, decreased susceptibility to injury, decreased width of hypertrophic chondrocyte zone, focal hepatic necrosis, impaired cued conditioning behavior, impaired macrophage chemotaxis, impaired macrophage phagocytosis, impaired neutrophil recruitment, increased circulating alanine transaminase level, increased hepatocellular carcinoma incidence, increased interleukin-12b secretion, increased interleukin-6 secretion, increased liver triglyceride level, increased liver weight, increased macrophage apoptosis, increased sensitivity to induced morbidity/mortality, increased susceptibility to parasitic infection, increased total body fat amount, increased tumor necrosis factor secretion, integument phenotype, oxidative stress, reproductive system phenotype, small intestinal inflammation [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (37 sources): Mallory bodies, abnormal CD8-positive, alpha-beta cytotoxic T cell morphology, abnormal circadian behavior, abnormal dendritic cell physiology, abnormal hepatocyte morphology, abnormal leukocyte physiology, abnormal long bone epiphyseal plate morphology, abnormal long bone hypertrophic chondrocyte zone, abnormal macrophage physiology, abnormal monocyte morphology, [+]