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Summary Expression Phenotypes Gene Literature (7) GO Terms (4) Nucleotides (229) Proteins (48) Interactants (274) Wiki
XB-GENEPAGE-984958

nf2     NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
decreased size of the head (4 sources), abnormal development of eye (3 sources), wholly anterioralized embryo (3 sources), wholly dorsalized embryo (3 sources), abnormal Wnt signaling pathway (1 source), absent head (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: nf2 manipulated (7 sources)
Computed annotations: nf2 assayed (2 sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + Nf2 MO (4 sources), Xla Wt + nf2 mKD (3 sources), Xla Wt + nf2 mKD (3 sources), Xla Wt + nf2 mKD (1 source), Xla Wt + nf2 mKD (1 source), Xla Wt + Nf2 MO (1 source), Xla Wt + Nf2 MO (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (108 sources): Abnormal brain FDG positron emission tomography, Abnormal central motor function, Abnormal central sensory function, Abnormal cerebellum morphology, Abnormal hypothalamus physiology, Abnormal kinetic perimetry test, Abnormal retinal vascular morphology, Abnormality of the mediastinum, Abnormality of the sense of smell, Abnormality of the skin, [+]
Mouse (62 sources): abnormal Schwann cell morphology, abnormal action potential, abnormal auditory brainstem response waveform shape, abnormal axon morphology, abnormal bile duct epithelium morphology, abnormal developmental patterning, abnormal dorsal-ventral axis patterning, abnormal embryonic tissue morphology, abnormal extraembryonic tissue morphology, abnormal lens epithelium morphology, [+]

View all ortholog results at Monarch