| Monarch Ortholog Phenotypes
|
|
Human (18 sources):
Abnormal cortical bone morphology,
Agenesis of corpus callosum,
Global developmental delay,
Gray matter heterotopia,
Growth delay,
Hyperreflexia,
Hypoplasia of the frontal lobes,
Intellectual disability, severe,
Ischemic stroke,
Microcephaly,
[+]
|
Mouse (37 sources):
abnormal T cell differentiation,
abnormal definitive hematopoiesis,
abnormal hematopoietic stem cell physiology,
abnormal hematopoietic system morphology/development,
abnormal lymphopoiesis,
abnormal spleen red pulp morphology,
abnormal thymocyte activation,
abnormal thymus morphology,
decreased DN1 thymic pro-T cell number,
decreased DN2 thymocyte number,
decreased DN4 thymocyte number,
decreased T cell proliferation,
decreased double-negative T cell number,
decreased double-positive T cell number,
decreased erythrocyte cell number,
decreased hematopoietic stem cell number,
decreased mature ovarian follicle number,
decreased thymocyte apoptosis,
decreased thymocyte number,
enlarged thymus,
immune system phenotype,
increased CD4-positive, alpha beta T cell number,
increased CD8-positive, alpha-beta T cell number,
increased DN1 thymic pro-T cell number,
increased DN3 thymocyte number,
increased T cell apoptosis,
increased double-negative T cell number,
increased hematopoietic stem cell number,
increased mean corpuscular hemoglobin concentration,
increased single-positive T cell number,
increased thymocyte number,
reduced female fertility,
small spleen,
small superior vagus ganglion,
small thymus,
thymus atrophy,
thymus cortex atrophy
[+]
|
View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.