| Monarch Ortholog Phenotypes
|
Human (55 sources):
Abdominal pain,
Abnormal pyramidal sign,
Agnosia,
Amaurosis fugax,
Anxiety,
Arthritis,
Attention deficit hyperactivity disorder,
Basal cell carcinoma,
Behavioral abnormality,
Benign neoplasm of the central nervous system,
Cardiac diverticulum,
Colon cancer,
Constipation,
Depression,
Developmental regression,
Dysarthria,
Dysgraphia,
Dyskinesia,
Failure to thrive,
Fatigue,
Flexion contracture,
Gait disturbance,
Gastrointestinal hemorrhage,
Glioblastoma multiforme,
Hallucinations,
Hemiplegia/hemiparesis,
Hepatocellular carcinoma,
Hereditary nonpolyposis colorectal carcinoma,
Hypotonia,
Increased intracranial pressure,
Intestinal polyposis,
Intractable diarrhea,
Irritability,
Malabsorption,
Memory impairment,
Migraine,
Nausea and vomiting,
Neoplasm of the pancreas,
Neoplasm of the rectum,
Neoplasm of the skeletal system,
Neoplasm of the thyroid gland,
Neuroblastoma,
Neurological speech impairment,
Ovarian neoplasm,
Pancreatic adenocarcinoma,
Paresthesia,
Pituitary adenoma,
Seizure,
Small for gestational age,
Spasticity,
Urinary tract neoplasm,
Villous atrophy,
Visual field defect,
Visual impairment,
Weight loss
[+]
|
Mouse (29 sources):
abnormal Langerhans cell morphology,
abnormal Langerhans cell physiology,
abnormal cell migration,
abnormal colon morphology,
abnormal crypts of Lieberkuhn morphology,
abnormal duodenum morphology,
abnormal enterocyte morphology,
abnormal enterocyte physiology,
abnormal enterocyte proliferation,
abnormal intestinal epithelium morphology,
abnormal intestinal mucosa morphology,
abnormal intestine physiology,
abnormal jejunum morphology,
abnormal placenta labyrinth morphology,
abnormal thrombosis,
behavior/neurological phenotype,
blunted small intestinal villi,
decreased body size,
decreased embryo size,
decreased trophoblast giant cell number,
delayed neural tube closure,
embryonic growth arrest,
embryonic lethality during organogenesis, complete penetrance,
increased susceptibility to type IV hypersensitivity reaction,
intestinal hemorrhage,
lethality during fetal growth through weaning, incomplete penetrance,
postnatal lethality, complete penetrance,
slow postnatal weight gain,
small intestinal inflammation
[+]
|
View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.