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XB-GENEPAGE-988577
tyr tyrosinase
Anatomical Phenotypes
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decreased pigmentation in the eye (7 sources), decreased pigmentation in the epidermis (6 sources), dead whole organism (2 sources), decreased pigmentation in the head (2 sources), decreased pigmentation in the whole organism (2 sources), abnormally decreased number of melanophore in the epidermis (1 source), absent eye (1 source), absent pigment cell (1 source), decreased pigmentation in the dorsal fin (1 source), decreased pigmentation in the retinal pigmented epithelium (1 source), decreased size of the eye (1 source), increased size of the ventral trunk (1 source) |
Expression Phenotypes
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Manual annotations: tyr assayed (1 source) |
Computed annotations: tyr assayed (5 sources) |
Diseases
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vitiligo (2AP sources), ocular albinism 1 (1AP source), oculocutaneous albinism type IA () |
Experiments (Reagents)
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Xla wt + tyr gRNA 14/16 CRISPR (2 sources), Xtr + tyr sgRNA CRISPR (2 sources), Xtr Wt + tyr CRISPR (2 sources), Xtr Wt + tyrm (2 sources), Xtr Wt + tyr CRISPR (1 source), Xtr Wt + tyr CRISPR (1 source), Xtr Wt + tyr CRISPR (1 source), Xtr Wt + tyr CRISPR (1 source), Xtr Wt + tyr CRISPR (1 source), Xtr Wt + tyr CRISPR (1 source), Xtr Wt + tyr CRISPR (4-600pg) (1 source) |
Monarch Ortholog Phenotypes
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Human (40 sources): Abnormality of refraction, Abnormality of retinal pigmentation, Abnormality of visual evoked potentials, Abnormal optic nerve morphology, Absent skin pigmentation, Albinism, Astigmatism, Basal cell carcinoma, Blue irides, Cutaneous photosensitivity, [+] |
Mouse (48 sources): abnormal aqueous drainage system morphology, abnormal cell morphology, abnormal cell nucleus morphology, abnormal chromosome morphology, abnormal coat appearance, abnormal eye pigmentation, abnormal hair follicle melanogenesis, abnormal keratinocyte apoptosis, abnormal melanosome morphology, abnormal miscarriage rate, [+] |
View all ortholog results at Monarch |