Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Phenotypes Gene Literature (22) GO Terms (11) Nucleotides (126) Proteins (28) Interactants (220) Wiki
XB-GENEPAGE-988577

tyr     tyrosinase

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
decreased pigmentation in the eye (6 sources), decreased pigmentation in the epidermis (3 sources), dead whole organism (2 sources), decreased pigmentation in the whole organism (2 sources), abnormally decreased number of melanophore in the epidermis (1 source), absent eye (1 source), absent pigment cell (1 source), decreased pigmentation in the head (1 source), decreased pigmentation in the retinal pigmented epithelium (1 source), decreased size of the eye (1 source), increased size of the ventral trunk (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: tyr assayed (1 source)
Computed annotations: tyr assayed (5 sources)
Diseases
Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
ocular albinism (1AP source), oculocutaneous albinism type IA ()
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla wt + tyr gRNA 14/16 CRISPR (2 sources), Xtr + tyr sgRNA CRISPR (2 sources), Xtr Wt + tyr CRISPR (2 sources), Xtr Wt + tyr CRISPR (1 source), Xtr Wt + tyr CRISPR (1 source), Xtr Wt + tyr CRISPR (1 source), Xtr Wt + tyr CRISPR (1 source), Xtr Wt + tyr CRISPR (1 source), Xtr Wt + tyr CRISPR (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (40 sources): Abnormality of refraction, Abnormality of retinal pigmentation, Abnormality of the optic nerve, Abnormality of visual evoked potentials, Absent skin pigmentation, Albinism, Astigmatism, Basal cell carcinoma, Blue irides, Cutaneous photosensitivity, [+]
Mouse (48 sources): abnormal aqueous drainage system morphology, abnormal cell morphology, abnormal cell nucleus morphology, abnormal chromosome morphology, abnormal coat appearance, abnormal eye pigmentation, abnormal hair follicle melanogenesis, abnormal keratinocyte apoptosis, abnormal melanosome morphology, abnormal miscarriage rate, [+]

View all ortholog results at Monarch