| Monarch Ortholog Phenotypes
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Human (23 sources):
Abnormality of the outer ear,
Buphthalmos,
Cataract,
Corneal opacity,
Esotropia,
Glaucoma,
Hyphema,
Iris coloboma,
Leukocoria,
Microcornea,
Microphthalmia,
Ocular anterior segment dysgenesis,
Ocular hypertension,
Pendular nystagmus,
Persistent pupillary membrane,
Phthisis bulbi,
Posterior synechiae of the anterior chamber,
Remnants of the hyaloid vascular system,
Retinal fold,
Retinal nonattachment,
Sclerocornea,
Shallow anterior chamber,
Uveitis
[+]
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Mouse (32 sources):
abnormal Muller cell morphology,
abnormal amacrine cell morphology,
abnormal circardian behavior entrainment,
abnormal eye development,
abnormal eye electrophysiology,
abnormal optic vesicle formation,
abnormal retinal bipolar cell morphology,
abnormal retinal cone bipolar cell morphology,
abnormal retinal cone cell morphology,
abnormal retinal ganglion cell morphology,
abnormal retinal ganglion layer morphology,
abnormal retinal nerve fiber layer morphology,
abnormal retinal rod bipolar cell morphology,
abnormal retinal vasculature morphology,
abnormal rod electrophysiology,
absent retinal ganglion cell,
absent retinal ganglion layer,
decreased optic chiasm size,
decreased retinal ganglion cell number,
decreased retinal rod cell number,
decreased total retina thickness,
increased amacrine cell number,
increased retinal apoptosis,
increased retinal cone cell number,
increased retinal photoreceptor cell number,
no abnormal phenotype detected,
reproductive system phenotype,
thin retinal inner nuclear layer,
thin retinal inner plexiform layer,
thin retinal outer nuclear layer,
thin retinal outer plexiform layer,
vision/eye phenotype
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.