| Monarch Ortholog Phenotypes
|
Human (23 sources):
Abnormality of the outer ear,
Buphthalmos,
Cataract,
Corneal opacity,
Esotropia,
Glaucoma,
Hyphema,
Iris coloboma,
Leukocoria,
Microcornea,
Microphthalmia,
Ocular anterior segment dysgenesis,
Ocular hypertension,
Pendular nystagmus,
Persistent pupillary membrane,
Phthisis bulbi,
Posterior synechiae of the anterior chamber,
Remnants of the hyaloid vascular system,
Retinal fold,
Retinal nonattachment,
Sclerocornea,
Shallow anterior chamber,
Uveitis
[+]
|
Mouse (32 sources):
abnormal amacrine cell morphology,
abnormal circardian behavior entrainment,
abnormal eye development,
abnormal eye electrophysiology,
abnormal Muller cell morphology,
abnormal optic vesicle formation,
abnormal retina bipolar cell morphology,
abnormal retina cone bipolar cell morphology,
abnormal retina cone cell morphology,
abnormal retina ganglion cell morphology,
abnormal retina ganglion layer morphology,
abnormal retina nerve fiber layer morphology,
abnormal retina rod bipolar cell morphology,
abnormal retina vasculature morphology,
abnormal rod electrophysiology,
absent retina ganglion cell,
absent retina ganglion layer,
decreased optic chiasm size,
decreased retina ganglion cell number,
decreased retina inner nuclear layer thickness,
decreased retina rod cell number,
decreased total retina thickness,
increased amacrine cell number,
increased retina apoptosis,
increased retina cone cell number,
increased retina photoreceptor cell number,
no abnormal phenotype detected,
reproductive system phenotype,
thin retina inner plexiform layer,
thin retina outer nuclear layer,
thin retina outer plexiform layer,
vision/eye phenotype
[+]
|
View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.