sptbn1 Phenotypes

Phenotypes

XB-GENEPAGE-989147

Gene Symbol: sptbn1 Gene Name: spectrin, beta, non-erythrocytic 1

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: sptbn1 assayed (3 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (38 sources): abnormal axon initial segment morphology, abnormal brain development, abnormal cell cycle checkpoint function, abnormal craniofacial morphology, abnormal digestive system morphology, abnormal fetal cardiomyocyte morphology, abnormal fetal cardiomyocyte physiology, abnormal heart development, abnormal heart ventricle wall thickness, abnormal myocardial fiber morphology, abnormal outer ear morphology, abnormal vitelline vasculature morphology, absent coronary vessels, adrenal gland cyst, decreased circulating alanine transaminase level, decreased embryo size, decreased fetal cardiomyocyte proliferation, decreased hepatocyte proliferation, decreased lactate dehydrogenase level, decreased mitotic index, increased adenoma incidence, increased adrenal cortical tumor incidence, increased body size, increased fetal cardiomyocyte apoptosis, increased glioma incidence, increased hepatocellular carcinoma incidence, increased liver tumor incidence, increased lymphoma incidence, increased renal carcinoma incidence, increased testis tumor incidence, increased thyroid carcinoma incidence, lethality throughout fetal growth and development, complete penetrance, liver hypoplasia, myocardial trabeculae hypoplasia, postnatal lethality, incomplete penetrance, premature death, small heart, thin ventricle myocardium compact layer [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (38 sources): abnormal axon initial segment morphology, abnormal brain development, abnormal cell cycle checkpoint function, abnormal craniofacial morphology, abnormal digestive system morphology, abnormal fetal cardiomyocyte morphology, abnormal fetal cardiomyocyte physiology, abnormal heart development, abnormal heart ventricle wall thickness, abnormal myocardial fiber morphology, [+]