Monarch Ortholog Phenotypes
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Mouse (29 sources):
abnormal axon morphology,
abnormal brain white matter morphology,
abnormal cerebellum fissure morphology,
abnormal cerebral cortex morphology,
abnormal hepatocyte morphology,
abnormal hippocampus pyramidal cell layer,
abnormal involuntary movement,
abnormal liver lobule morphology,
abnormal motor capabilities/coordination/movement,
abnormal Purkinje cell morphology,
axonal dystrophy,
axonal spheroids,
brain vacuoles,
decreased cerebral cortex pyramidal cell number,
decreased hippocampus pyramidal cell number,
decreased myelin sheath thickness,
decreased neuron number,
decreased Purkinje cell number,
enlarged lateral ventricles,
impaired autophagy,
increased neuron apoptosis,
limb grasping,
nervous system phenotype,
neuronal cytoplasmic inclusions,
premature death,
prenatal lethality, complete penetrance,
reduced cerebellar foliation,
thin cerebellar molecular layer,
thin cerebral cortex
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