ddx3x Phenotypes

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Phenotypes

Gene Literature (16)

Nucleotides (1235)

Interactants (189)

XB-GENEPAGE-999730

Gene Symbol: ddx3x Gene Name: DEAD-box helicase 3 X-linked

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal cartilage tissue morphology (3 sources), decreased size of the cranial skeleton (3 sources), abnormal Wnt signaling pathway (2 sources), increased size of the neural crest (1 source), increased size of the neural plate border (1 source), increased size of the presumptive midbrain-hindbrain boundary (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: ddx3x manipulated (5 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + ddx3x MO (5 sources), Xtr.Tg(snai2:eGFP)Swei + ddx3x MO (2 sources), Xtr Wt + ddx3x (1 source), Xtr.Tg(snai2:eGFP)Swei + ddx3x MO (1 source), Xtr.Tg(WntREs:dEGFP)Vlemx + ddx3x MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (65 sources): Abnormal cardiac septum morphology, Abnormal cardiovascular system morphology, Abnormal facial shape, Abnormal pinna morphology, Abnormality of skin pigmentation, Abnormality of the larynx, Abnormality of vision, Agenesis of corpus callosum, Aggressive behavior, Anteriorly placed anus, Anteverted nares, Autistic behavior, Blepharophimosis, Brachydactyly, Broad-based gait, Cardiomyopathy, Cerebellar hypoplasia, Cleft palate, Cleft upper lip, Clinodactyly, Cortical dysplasia, Cryptorchidism, Decreased body weight, Depressed nasal bridge, Downturned corners of mouth, Dyskinesia, Full cheeks, Generalized hypotonia, Global developmental delay, Hearing impairment, Hernia, Hyperactivity, Hypertelorism, Hypoplasia of the corpus callosum, Hypospadias, Hypotonia, Intellectual disability, Laryngeal hypoplasia, Microcephaly, Micrognathia, Narrow chest, Neonatal respiratory distress, Orofacial cleft, Patent ductus arteriosus, Pierre-Robin sequence, Precocious puberty, Proximal placement of thumb, Ptosis, Redundant neck skin, Respiratory distress, Scoliosis, Seizure, Short neck, Short nose, Short palm, Short palpebral fissure, Spasticity, Syndactyly, Telecanthus, Tracheal stenosis, Tracheomalacia, Ventriculomegaly, Visual impairment, Wide anterior fontanel, obsolete Joint laxity [+]
Mouse (22 sources): abnormal allantois morphology, abnormal brain development, abnormal developmental patterning, abnormal embryo turning, abnormal head fold morphology, abnormal placenta vasculature, abnormal placental labyrinth vasculature morphology, abnormal trophoblast giant cell morphology, decreased spongiotrophoblast cell number, decreased spongiotrophoblast size, decreased trophoblast giant cell number, embryonic growth retardation, embryonic lethality between implantation and placentation, embryonic lethality prior to organogenesis, embryonic lethality prior to tooth bud stage, failure of chorioallantoic fusion, increased embryonic tissue cell apoptosis, increased mitotic index, lethality throughout fetal growth and development, incomplete penetrance, no abnormal phenotype detected, preweaning lethality, complete penetrance, small allantois [+]
View all ortholog results at Monarch