The ksr1 gene encodes a scaffold protein that modulates ras/MAPK signaling pathways during embryogenesis. It facilitates signal transduction from activated RAF to MEK and ERK, particularly in response ...[+]

The ksr1 gene encodes a scaffold protein that modulates ras/MAPK signaling pathways during embryogenesis. It facilitates signal transduction from activated RAF to MEK and ERK, particularly in response to FGF signaling. The protein is cytoplasmic and membrane-associated, influencing mesoderm induction, neural development, and tissue morphogenesis. Its expression and function are documented in the ectoderm, mesoderm, and developing neural tissue. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD