The cd4 gene encodes a membrane glycoprotein that functions as a T cell coreceptor. This protein is located on the plasma membrane of T lymphocytes and interacts with major histocompatibility complex (...[+]

The cd4 gene encodes a membrane glycoprotein that functions as a T cell coreceptor. This protein is located on the plasma membrane of T lymphocytes and interacts with major histocompatibility complex (MHC) class II molecules and the lck tyrosine kinase to facilitate signal transduction during antigen presentation and T cell activation. Its expression is detected in the thymus and spleen. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD