The ldb1 gene encodes a lim domain-binding transcriptional cofactor that localizes to the nucleus. It physically interacts with transcription factors such as lhx1 and isl1, forming complexes that bind ...[+]

The ldb1 gene encodes a lim domain-binding transcriptional cofactor that localizes to the nucleus. It physically interacts with transcription factors such as lhx1 and isl1, forming complexes that bind DNA through its lim domains to regulate gene expression during embryonic development. Its functions are associated with patterning of the neural tube, notochord, somites, and pronephros. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD