The ap2a1 gene encodes a subunit of the adaptor protein complex 2 (ap-2), which functions in clathrin-mediated endocytosis at the plasma membrane to facilitate vesicle formation for neurotransmitter up...[+]

The ap2a1 gene encodes a subunit of the adaptor protein complex 2 (ap-2), which functions in clathrin-mediated endocytosis at the plasma membrane to facilitate vesicle formation for neurotransmitter uptake and receptor internalization. In development, it is expressed in neural crest cells, cranial ganglia, skin, eyes, and otic vesicles. The ap2a1 protein localizes to the plasma membrane and golgi apparatus. [-]

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