The zdhhc7 gene encodes a DHHC-type palmitoyltransferase enzyme. This enzyme catalyzes the palmitoylation of target proteins, a post-translational modification critical for protein-membrane association...[+]

The zdhhc7 gene encodes a DHHC-type palmitoyltransferase enzyme. This enzyme catalyzes the palmitoylation of target proteins, a post-translational modification critical for protein-membrane association, trafficking, and function. In Xenopus laevis and Xenopus tropicalis, the zdhhc7 protein localizes to the endoplasmic reticulum and Golgi apparatus. It is essential for proper neural development, influencing processes such as neural crest cell migration, axon guidance, and synaptogenesis. Expression is prominent in the developing nervous system, including the neural tube, brain, and sensory organs. The protein's activity is vital for nervous system development and function, with mutations or disruptions linked to neurodevelopmental defects. The protein contains a conserved DHHC catalytic domain and transmembrane domains, characteristic of the DHHC family of palmitoyltransferases. [-]

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